SLU, the BLOG for UW and biology at SLU

Breakfast Club: Tue., Feb. 14, 2012 - Galis (remote webcast)

2012-02-07T15:09:00.000-08:00

To view the webcast, go to: http://tcs.slu.washington.edu/tcs/?id=b5973322-47e8-466f-963a-25ca55bb12ddThe Center for Cardiovascular Biology Breakfast Club meets on Tuesday mornings under the sponsorship of the Stem Cells and Cardiovascular Repair program project grant, training grants in Cardiovascular Pathology and Cardiology, and the Mitochondria and Metabolism Center.REMOTE WEBCASTZorina Galis, Ph.D. Chief, Vascular Biology and Hypertension BranchDivision of Cardiovascular Sciences, NHLBI (Host: Steve Schwartz, UW Pathology)“An NHLBI Perspective on challenges and opportunities in cardiovascular research”Tuesday, February 14, 20129:00 – 10:00 a.m.UW SLU campus, 815 Mercer StreetOrin Smith Auditorium, Admin Bldg. C

Breakfast Club: Tue., Feb. 7, 2012 - Harrison (remote webcast)

2012-01-31T15:50:00.000-08:00

To view the webcast, CLICKME ---- NOTE UPDATED LINK.

The Center for Cardiovascular Biology Breakfast Club meets on Tuesday mornings under the sponsorship of the Stem Cells and Cardiovascular Repair program project grant, training grants in Cardiovascular Pathology and Cardiology, and the Mitochondria and Metabolism Center.REMOTE WEBCASTDavid Harrison, MD, FACC, FAHA Betty and Jack Bailey Professor of Medicine and Pharmacology; Director, Division of Clinical PharmacologyVanderbilt University School of Medicine(Host: Steve Schwartz, UW Pathology)“Adaptive Immunity & Hypertension”Tuesday, February 7, 20129:00 – 10:00 a.m.UW SLU campus, 815 Mercer StreetOrin Smith Auditorium, Admin Bldg. C

Breakfast Club: Mon., Jan. 30, 2012 - Molkentin, Distinguished Lecture

2012-01-25T11:42:00.000-08:00

NOTE THE DAY AND DATE OF THE LECTURE.To view the webcast, please go to: http://tcs.slu.washington.edu/tcs/?id=2fcae03b-ec2c-4963-a5ff-fd828d455eebThe Center for Cardiovascular Biology Breakfast Club meets on Tuesday mornings under the sponsorship of the Stem Cells and Cardiovascular Repair program project grant, training grants in Cardiovascular Pathology and Cardiology, and the Mitochondria and Metabolism Center.DISTINGUISHED LECTUREJeffery D. Molkentin, Ph.D.ProfessorHoward Hughes Medical Institute InvestigatorChildren’s Hospital, Cincinnati, OH(Faculty Host: Rong Tian, UW Mitochondria and Metabolism Center)PKCalpha as a novel therapeutic target in heart failureMonday, January 30, 2012 9:00 – 10:00 a.m.UW SLU campus, 815 Mercer StreetOrin Smith Auditorium, Admin Bldg. C

Breakfast Club: Tue., Jan. 31, 2012 - Yoshimura

2012-01-25T11:27:00.000-08:00

To view the webcast, go to: http://tcs.slu.washington.edu/tcs/?id=b678e936-e0cf-4b37-a26c-ce2d4b90b4e6The Center for Cardiovascular Biology Breakfast Club meets on Tuesday mornings under the sponsorship of the Stem Cells and Cardiovascular Repair program project grant, training grants in Cardiovascular Pathology and Cardiology, and the Mitochondria and Metabolism Center.Shinichi Yoshimura, M.D., Ph.D.Clinical Professor, Department of Neurosurgery Gifu University, Japan(Host: Tom Hatsukami, Co-Director, UW Vascular Imaging Laboratory)“Application of Optical Coherence Tomography (OCT) to Human Carotid Artery”Tuesday, January 31, 20129:00 – 10:00 a.m.UW SLU campus, 815 Mercer StreetOrin Smith Auditorium, Admin Bldg. C

Brerakfast Club: Tue., Jan. 24, 2012 - Keshet (Distinguished Lecture)

2012-01-19T23:14:00.000-08:00

The Center for Cardiovascular Biology Breakfast Club meets on Tuesday mornings under the sponsorship of the Stem Cells and Cardiovascular Repair program project grant, training grants in Cardiovascular Pathology and Cardiology, and the Mitochondria and Metabolism Center.DISTINGUISHED LECTUREEli Keshet, Ph.D.Dept. of Developmental Biology & Cancer ResearchThe Hebrew University-Hadassah Medical SchoolJerusalem, Israel(Faculty Host: Stephen M. Schwartz, UW Pathology)'Non-traditional' functions of VEGF and the vasculatureTuesday, January 24, 2012 9:00 – 10:00 a.m.UW SLU campus, 815 Mercer StreetOrin Smith Auditorium, Admin Bldg. C

ISCRM Symposium Jan 12.

2012-01-05T10:28:00.000-08:00

Breakfast Club: Tue., January 10, 2011: Zheng

2012-01-02T21:09:00.000-08:00

The Center for Cardiovascular Biology Breakfast Club meets on Tuesday mornings under the sponsorship of the Stem Cells and Cardiovascular Repair program project grant, training grants in Cardiovascular Pathology and Cardiology, and the Mitochondria and Metabolism Center.Ying Zheng, Ph.D.Research Assistant Professor, Department of Bioengineering University of Washington(Host: Stephen M. Schwartz, UW Department of Pathology)“Engineering microvasculature for the study of cardiovascular development and diseases”Tuesday, January 10, 20129:00 – 10:00 a.m.UW SLU campus, 815 Mercer StreetOrin Smith Auditorium, Admin Bldg. C

Breakfast Club: Tue. Dec. 20, 2011 - Lau

2011-12-15T12:41:00.000-08:00

Please post the attached flyer. Please note the venue for this talk is at Brotman Auditorium. Url for live streaming and recording to be announced laterThe Center for Cardiovascular Biology Breakfast Club meets on Tuesday mornings under the sponsorship of the Stem Cells and Cardiovascular Repair program project grant, training grants in Cardiovascular Pathology and Cardiology, and the Mitochondria and Metabolism Center.Wei Ling Lau, M.D.Fellow, Department of Nephrology University of Washington(Host: Ceci Giachelli, UW Departments of Bioengineering, Pathology, and Oral Biology)“Effects of vitamin D therapy in a mouse model of uremic vascular calcification”Tuesday, December 20, 20119:00 – 10:00 a.m.UW SLU campus, 815 Mercer StreetBrotman Auditorium

Doctoral Dissertation: Thu., Dec. 8, 4:30 pm, Orin Smith Auditorium: Ingrid HartenIngrid

2011-12-08T14:35:00.001-08:00

Doctoral Dissertation Ingrid Harten Department of Pathology Graduate Student University of Washington School of Medicine An Analysis of the Extracellular Matrix in Hutchinson Gilford Progeria Syndrome Thursday, December 8, 2011 at 4:30 PM UW Medicine South Lake Union Orin Smith Auditorium Faculty Sponsor: Thomas Wight, Ph.D. Please visit the following website to view the live webcast of Ingrid’s defense: http://tcs.slu.washington.edu/tcs/#page:recordingList&pageNumber:1

2011-12-07T11:58:00.001-08:00

Stem Cell Talk

2011-12-06T15:28:00.001-08:00

Jeffrey Macklis, M.D., D.HST

Professor of Stem Cell and Regenerative Biology

Harvard University

Program Head, Neuroscience / Nervous System Diseases

Harvard Stem Cell Institute

Molecular Logic of Neocortical Projection Neuron Development, Degeneration, and Regeneration

Wednesday, December 7, 2011 at 4:30 PM

Health Sciences Center

Room K-069

Faculty Host: Chuck Murry, M.D., Ph.D.

Breakfast Club: Tue., Nov. 22, 2011 - Giachelli

2011-11-16T10:35:00.000-08:00

To view the webcast, go to:
tcs.slu.washington.edu

The Center for Cardiovascular Biology Breakfast Club meets on Tuesday mornings under the sponsorship of the Stem Cells and Cardiovascular Repair program project grant, training grants in Cardiovascular Pathology and Cardiology, and the Mitochondria and Metabolism Center.

Cecilia M. Giachelli, Ph.D.
Professor of Bioengineering
Adjunct Professor of Pathology
Adjunct Professor of Oral Biology
University of Washington

(Host: Charles E. Murry, UW Departments of Pathology, Bioengineering, and Medicine/Cardiology)

“Mechanisms of Vascular Calcification”

Tuesday, November 22, 2011
9:00 – 10:00 a.m.
UW SLU campus, 815 Mercer Street
Orin Smith Auditorium, Admin Bldg. C

Breakfast Club: Tue., Nov. 15, 2011 - Smith

2011-11-10T14:42:00.000-08:00

To view the webcast, go to:
tcs.slu.washington.edu

The Center for Cardiovascular Biology Breakfast Club meets on Tuesday mornings under the sponsorship of the Stem Cells and Cardiovascular Repair program project grant, training grants in Cardiovascular Pathology and Cardiology, and the Mitochondria and Metabolism Center.

Kelly D. Smith, M.D., Ph.D.
Associate Professor
Department of Pathology
University of Washington

(Host: Karin Bornfeldt, UW Department of Pathology & DOCE)

“Mucosal innate immunity to Salmonella infection”

Tuesday, November 15, 2011
9:00 – 10:00 a.m.
UW SLU campus, 815 Mercer Street
Orin Smith Auditorium, Admin Bldg. C

Special Brekafst Club: Mon., Nov. 7, 2011 - Murphy

2011-11-04T16:46:00.001-07:00

“What do you need to make a muscle?
The role of muscle stem cells and connective tissue fibroblasts in muscle regeneration”

Talk by Ph.D. Candidate

Malea M. Murphy
Department of Human Genetics
University of Utah
Salt Lake City, Utah

Monday, November 7, 1 p.m.
Orin Smith Auditorium
South Lake Union Campus, 815 Mercer Street
Sponsored by Jeremy Duffield, MD, PhD, in the Center for Lung Biology

Breakfast Club: Tue., Nov. 8, 2011 - Bajjalieh

2011-11-04T16:37:00.000-07:00

The Center for Cardiovascular Biology Breakfast Club meets on Tuesday mornings under the sponsorship of the Stem Cells and Cardiovascular Repair program project grant, training grants in Cardiovascular Pathology and Cardiology, and the Mitochondria and Metabolism Center.

Sandra M. Bajjalieh, Ph.D.
Professor, Department of Pharmacology
University of Washington

(Host: Joe Beavo, UW Department of Pharmacology)

“There and back again: Regulating exocytosis through endocytosis”

Tuesday, November 8, 2011
9:00 – 10:00 a.m.
UW SLU campus, 815 Mercer Street
Brotman Auditorium

*Please note the venue

Breakfast Club: Tue., Nov. 1, 2011 - Liu

2011-10-26T11:10:00.000-07:00

To view the webcast, go to:
tcs.slu.washington.edu

The Center for Cardiovascular Biology Breakfast Club meets on Tuesday mornings under the sponsorship of the Stem Cells and Cardiovascular Repair program project grant, training grants in Cardiovascular Pathology and Cardiology, and the Mitochondria and Metabolism Center.

Qinghang (Chris) Liu, Ph.D.
Assistant Professor
Departments of Physiology and Biophysics
University of Washington

(Host: Rong Tian, UW Mitochondria and Metabolism Center)

“Role of TAK1 Signaling Network in Cardiac Hypertrophy and Remodeling”

Tuesday, November 1, 2011
9:00 – 10:00 a.m.
UW SLU campus, 815 Mercer Street
Orin Smith Auditorium, Admin Bldg. C

Breakfast Club: Tue., Oct. 25, 2011 - Lindner (Webinar from Porrtland)

2011-10-19T15:10:00.000-07:00

To view the webcast, go to:
tcs.slu.washington.edu

The Center for Cardiovascular Biology Breakfast Club meets on Tuesday mornings under the sponsorship of the Stem Cells and Cardiovascular Repair program project grant, training grants in Cardiovascular Pathology and Cardiology, and the Mitochondria and Metabolism Center.

Jonathan R. Lindner, M.D.
Professor of Medicine
Associate Chief for Education, Cardiovascular Division
Oregon Health & Science University
Division of Cardiovascular Medicine
Portland, Oregon
(Host: Steve Schwartz, UW Pathology)

Webinar from Portland, OR
“Molecular Imaging in Cardiovascular Research”

Tuesday, October 25, 2011
9:00 – 10:00 a.m.
UW SLU campus, 815 Mercer Street
Orin Smith Auditorium, Admin Bldg. C

Breakfast Club: Tue., Oct. 18, 2011 - Lopez

2011-10-12T13:38:00.000-07:00

To view the webcast, go to:
tcs.slu.washington.edu

The Center for Cardiovascular Biology Breakfast Club meets on Tuesday mornings under the sponsorship of the Stem Cells and Cardiovascular Repair program project grant, training grants in Cardiovascular Pathology and Cardiology, and the Mitochondria and Metabolism Center.

José A. López, M.D.
Executive Vice-President for Research
Puget Sound Blood Center
Professor, Departments of Medicine and Biochemistry, University of Washington
(Host: Bill Parks, UW Center for Lung Biology)

“von Willebrand factor: friend or foe?”

Tuesday, October 18, 2011
9:00 – 10:00 a.m.
UW SLU campus, 815 Mercer Street
Orin Smith Auditorium, Admin Bldg. C

2011-10-07T15:51:00.001-07:00

2011/2012 kick-off ISCRM Research Update

Tuesday, October 11, 2011

4:00 - 5:00PM

Brotman Auditorium, SLUcampus

815 Mercer Street

Presenters:

Wenyu Zhouwill give a presentation on “Differential roles of hypoxia inducible factor in the acquisition of pluripotency" for Hannele Ruohola Baker's lab

Alvin Liuwill talk about “Reprogramming of diseased cell types in prostate cancer" for his lab

2011-10-06T17:14:00.001-07:00

Mendel 2.0: Transgenerational Genetic Effects on Phenotypic Variation and Disease Risk

Speaker: Joseph Nadeau, PhD
Institute for Systems Biology

Date: October 10th, 2011

Time: 11:00 am

Place: Pelton Auditorium

2011-10-05T11:34:00.001-07:00

Speaker: Steven Kattman, Ph.D.
Title: "Industrial generation of human iPSC-derived cardiomyocytes for modeling cardiac function and disease"
Date: Monday, October 10th
Time: 1:00-2:00 pm
Location: Orin Smith Auditorium, SLU campus

Breakfast Club: Tue., October 4, 2011 - Noble

2011-09-28T12:54:00.000-07:00

To view the webcast, go to:
tcs.slu.washington.edu

The Center for Cardiovascular Biology Breakfast Club meets on Tuesday mornings under the sponsorship of the Stem Cells and Cardiovascular Repair program project grant, training grants in Cardiovascular Pathology and Cardiology, and the Mitochondria and Metabolism Center.

William Stafford Noble, Ph.D.
Professor
Department of Genome Sciences
University of Washington

(Host: Zhi-jun Duan, UW Hematology; ISCRM)

“The one-dimensional and three-dimensional architecture of the genome”

Tuesday, October 4, 20119:00 – 10:00 a.m.
UW SLU campus, 815 Mercer Street
Orin Smith Auditorium, Admin Bldg. C

2011-09-28T11:50:00.001-07:00

First Tueday of October: about midnoght, wait up for the Nobels

2011-09-21T15:20:00.000-07:00

Wikimedia, Zero Grey

The Karolinska is going to wake up one to three biologists and announce they have won the Nobel Prize.

Thompson Reuters has their list based on citation, I call this hokey.

Here is Thompsons's list with my thumb added where I think they may be right. Then I added my own gueses. Finally, I have added some UW names I think may want to wait for the phone call.

Physiology or Medicine

Brian J. Druker (Oregon Health & Science University oncologist), Nicholas B. Lydon (founder of several biotech companies including Granite Biopharma, AnaptysBio, and Blueprint Medicines),and Charles L. Sawyers (Memorial Sloan-Kettering Cancer Center oncologist) “for their development of imatinib and dasatinib, revolutionary, targeted treatments for chronic myeloid leukemia”

Robert S. Langer (Massachusetts Institute of Technology chemical engineer) and Joseph P. Vacanti (Harvard Medical School professor of surgery) “for their pioneering research in tissue engineering and regenerative medicine”

Jacques F. A. P. Miller (University of Melbourne researcher) “for his discovery of the function of the thymus and the identification of T cells and B cells in mammalian species”

Robert L. Coffman (vice president and chief scientific officer, Dynavax Technologies) and Timothy R. Mosmann (University of Rochester Medical Center immunologist) “for their discovery of two types of T lymphocytes, TH1 and TH2, and their role in regulating host immune response”

And here is my list:

Shinya Yamanaka, Irv Weissman, Reudi Yaenish Tokyo, Gladstone, Stanford, MIT the stem cell

Eric Lander, Phil Green MIT, Harvard, UW human genome project

Ruslan Medzhitov Yale The innate immune system.

Brian Druker, anti kinase therapy in cancer Oregon

These Names Here Deserve Nobels:

Earl Davies, blood coagulation

Phil Green, genome informatics

John Harlan, endothelial cell interactions with leukocytes

Jerry Nepom, immunology of type 1 diabetes

Lee Hood, Bob Waterston genome project

Arno Motulsky, Maynard Olsen, Mark Groudine not sure for what because they have done so much

Breakfast Club: Tue., Sept. 27, 2011 - Parks

2011-09-20T09:49:00.001-07:00

To view the webcast, go to:
tcs.slu.washington.edu

The Center for Cardiovascular Biology Breakfast Club meets on Tuesday mornings under the sponsorship of the Stem Cells and Cardiovascular Repair program project grant, training grants in Cardiovascular Pathology and Cardiology, and the Mitochondria and Metabolism Center.

William C. Parks, Ph.D.
Professor, Division of Pulmonary and Critical Care Medicine and Director, Center for Lung Biology, University of Washington
Affiliate Investigator, Benaroya Research Institute

(Host: Kelly Smith, UW Pathology)

“Proteolytic Pathways in Immunity, MMPs as Effectors of Inflammation”

Tuesday, September 27, 2011
9:00 – 10:00 a.m.
UW SLU campus, 815 Mercer Street
Orin Smith Auditorium, Admin Bldg. C

2011-09-20T08:34:00.000-07:00

Top 7 in Genomics & Genetics

A snapshot of the most highly ranked articles in genomics, genetics and related areas, from Faculty of 1000

HIV budding from cell membrane. Wikimedia Commons, NIH

1. Lighting up RNA
A novel technique for tagging and following RNA processes in live cells promises to illuminate RNA biology the way green fluorescent protein (GFP) did for the study of proteins. The tagging method consists of short RNA sequences that bind to GFP-like fluorophores and produce a wide range of colors. These RNA-fluorophore complexes can then be fused to RNAs in the cell.
J.S. Paige et al., “RNA mimics of green fluorescent protein,” Science, 333:642-46, 2011. Free F1000 Evaluation
2. I Spy
Researchers testing the ability of engineered E. coli cells to stabilize unstable proteins in vivo, stumbled upon a new protein chaperone, called Spy, that suppresses protein aggregation and aids protein refolding. Spy is shaped unlike any other previously studied chaperone and can increase the steady-state levels of a set of unstable protein mutants up to 700-fold.
S. Quan et al., “Genetic selection designed to stabilize proteins uncovers a chaperone called Spy,” Nat Struct Mol Biol, 18:262-69, 2011. Free F1000 Evaluation
3. Gene expression goes global
Protein levels are regulated by the interplay not merely of protein translation and degradation, but mRNA transcription and destruction. In this first investigation into genome-scale prediction of mRNA and protein synthesis rates, researchers measured both RNA abundance and protein turnover of over 5000 genes, and found that the abundance of proteins in a cell is primarily controlled at the translational level.
B. Schwanhäusser et al., “Global quantification of mammalian gene expression control,” Nature, 473:337-42, 2011. Free F1000 Evaluation
4. Why DNA breaks
Chromosome instability—the propensity of certain places in the genome to break under replicative stress—can contribute to tumorigenesis. Previous work suggested that such common fragile sites were prone to breakage because of secondary structures that arose during replication and blocked the formation of replication forks. In contrast, this study shows that at least one site, FRA3B, is unstable even when few replication events are initiated, suggesting another mechanism must be responsible for the site’s fragility.
A. Letessier et al., “Cell-type specific replication initiation programs set fragility of the FRA3B fragile site,” Nature, 470:120-23, 2011. Free F1000 Evaluation
5. Odd cod immunity
The full genome sequence of the Atlantic cod reveals that the fish have lost the genes for MHCII and CD4, two key players in immunity. Apparently in compensation, the cod’s genome shows that MHC I locus is greatly expanded, and contains a unique complement of Toll-like receptors, another important component of the immune system.
B. Star et al., “The genome sequence of Atlantic cod reveals a unique immune system,” Nature, 477:207-10, 2011. Free F1000 Evaluation
6. HIV evades NK death
Just as T cells are able to pressure HIV to adapt to escape recognition, it now appears NK cells also can drive HIV evolution. Researchers identified polymorphisms in strains of HIV-1 that prevented activation of NK cells with specific killer immunoglobulin-like receptors (KIRs).
G. Alter et al., “HIV-1 adaptation to NK-cell-mediated immune pressure,” Nature, 476:96-100, 2011. Free F1000 Evaluation
7. Molecular fountain of youth?
Replicating cells of complex organisms can reset the cellular clock of progeny, essentially resetting their age. Researchers identify a transcription factor called NDT80, which is essential for gametogenesis in budding yeast, that makes this possible, allowing yeast cells to extend the number of times they replicate. Transient expression of NDT80 in yeast cells that weren’t undergoing gametogenesis could also reset their life span.
E. Unal et al., “Gametogenesis eliminates age-induced cellular damage and resets life span in yeast,” Science, 332:1554-47, 2011. Free F1000 Evaluation

The F1000 Top 7 is a snapshot of the highest ranked articles from a 30-day period on Faculty of 1000 Genomics & Genetics, as calculated on September 15, 2011. Faculty Members evaluate and rate the most important papers in their field. To see the latest rankings, search the database, and read daily evaluations, visit http://f1000.com.

Breakfast Club: MONDAY, Sept. 19, 2011 - Field

2011-09-13T11:21:00.001-07:00

THIS LECTURE WILL NOT BE STREAMED OR RECORDED

The Center for Cardiovascular Biology Breakfast Club meets on Tuesday mornings under the sponsorship of the Stem Cells and Cardiovascular Repair program project grant, training grants in Cardiovascular Pathology and Cardiology, and the Mitochondria and Metabolism Center.

DISTINGUISHED LECTURE

Loren J. Field, Ph.D.
Professor of Medicine and Pediatrics
Indiana University School of Medicine

(Faculty Host: Chuck Murry, UW Pathology, Bioengineering and Medicine/Cardiology)

“Mechanisms for Cardioprotection and Regeneration”

Monday, September 19, 2011 (Note special date)
9:00 – 10:00 a.m.
UW SLU campus, 815 Mercer Street
Orin Smith Auditorium, Admin Bldg. C

Webinar: Tue., Sept. 13, 1 pm - James

2011-09-12T11:01:00.000-07:00

Webinar: Tuesday September 13, 1pm PST / 4pm EST
Effects of shear stress on uterine vasculature remodeling

Webinar: Tuesday September 13, 2011
Time: 1pm PST / 4pm EST
Speaker: Dr. Jo James, University of Auckland

In this webinar, Dr. Jo James will present her research on the uterine vasculature remodeling process during pregnancy. She will describe her development of an in vitro assay with controlled shear stress and timelapse microscopy to simulate the conditions seen by trophoblasts and further examine their role in migration and endothelial cell apoptosis.

Dr. Jo James

BioFlux System

More about Dr. Jo James

Dr. James undertook her PhD at the University of Auckland, New Zealand, looking at the differentiation of specialized cells in the placenta termed trophoblasts and the effects of hypoxia on this process. She then moved to the UK where she has spent the past three years undertaking a New Zealand Foundation of Research Science and Technology fellowship at St George's University of London investigating the effects of low shear stress on the remodeling of the uterine vasculature by trophoblasts. This is a highly specialized process which involves the trophoblast migrating down the arteries, integrating into the endothelial cell layer and replacing these cells by inducing endothelial and smooth muscle cell apoptosis. This results in the uterine arteries increasing in diameter and losing their ability to regulate muscle tone such that they become independent of maternal vasoconstriction. This process is essential in order to deliver an adequate supply of blood to the growing baby, and when it is insufficient results in disorders of pregnancy including pre-eclampsia and babies that are born small. Both these complications can have life threatening consequences for both mother and baby. Low shear stress is believed to be important for uterine artery remodeling as the arteries are plugged by the trophoblasts for the first 10 weeks of the pregnancy, resulting in a slow high-resistance blood flow in these vessels. Dr. James' work using the BioFlux in combination with timelapse microscopy has shown that low shear stress during this time is important to allow trophoblast to migrate down the arteries, and aids trophoblast-induced endothelial apoptosis. Dr James has recently returned to the University of Auckland to begin a new fellowship investigating the presence of trophoblast stem cells in first trimester placenta, and hopes to tie these two interests together eventually by examining the effects of shear stress on trophoblast stem cell differentiation in the future.

Breakfast Club: Tue., Sept. 13, 2011 - Dong

2011-09-07T15:06:00.001-07:00

There will be no webcast or recording of this talk.

The Center for Cardiovascular Biology Breakfast Club meets on Tuesday mornings under the sponsorship of the Stem Cells and Cardiovascular Repair program project grant, training grants in Cardiovascular Pathology and Cardiology, and the Mitochondria and Metabolism Center.

Jing-Fei Dong, M.D., Ph.D.Full Member, Puget Sound Blood Center Research Institute
Professor of Medicine, Div. of Hematology, Univ. of Washington

Hosted by: William C. Parks, Center for Lung Biology

“Platelet Hyperactivity and Inflammation: STAT3 Signaling in Platelets”

Tuesday, September 13, 20119:00 – 10:00 a.m.
UW SLU campus, 815 Mercer Street
Orin Smith Auditorium, Admin Bldg. C

Breakfast Club: Tue., September 6, 2011 - Santana

2011-08-31T22:46:00.001-07:00

To view the webcast, go to:
tcs.slu.washington.edu

The Center for Cardiovascular Biology Breakfast Club meets on Tuesday mornings under the sponsorship of the Stem Cells and Cardiovascular Repair program project grant, training grants in Cardiovascular Pathology and Cardiology, and the Mitochondria and Metabolism Center.

Luis F. Santana, Ph.D.
Professor
Department of Physiology and Biophysics
University of Washington

“Local Controls of L-type Calcium Channels in Muscle”

Tuesday, September 6, 2011
9:00 – 10:00 a.m.
UW SLU campus, 815 Mercer Street
Orin Smith Auditorium, Admin Bldg. C

Breakfast Club: Tue., June 21, 2011 - Houser

2011-06-15T09:34:00.001-07:00

To view the webcast, go to:
tcs.slu.washington.edu

The Center for Cardiovascular Biology Breakfast Club meets on Tuesday mornings under the sponsorship of the Stem Cells and Cardiovascular Repair program project grant, training grants in Cardiovascular Pathology and Cardiology, and the Mitochondria and Metabolism Center.

Steven R. Houser, Ph.D., FAHA
Laura H. Carnell Professor of Physiology and Medicine
Director, Cardiovascular Research Group
Chair, Department of Physiology
Temple University School of Medicine
Philadelphia, PA
(Host: Rong Tian, UW Mitochondria and Metabolism Center)

DISTINGUISHED LECTURE

“Ca2+ Mediated Myocyte Hypertrophy, Death, and Regeneration”

Tuesday, June 21, 2011
9:00 – 10:00 a.m.
UW SLU campus, 815 Mercer Street
Orin Smith Auditorium, Admin Bldg. C

Breakfast Club: Tue., June 14, 2011: Karamanlidis

2011-06-08T13:50:00.001-07:00

To view the webcast, go to:
tcs.slu.washington.edu

The Center for Cardiovascular Biology Breakfast Club meets on Tuesday mornings under the sponsorship of the Stem Cells and Cardiovascular Repair program project grant, training grants in Cardiovascular Pathology and Cardiology, and the Mitochondria and Metabolism Center.

Georgios Karamanlidis, Ph.D.
Postdoctoral Fellow
Mitochondria and Metabolism Center
University of Washington
(Host: Rong Tian, UW Mitochondria and Metabolism Center)

“Mitochondria beyond ATP production”

Tuesday, June 14, 2011
9:00 – 10:00 a.m.
UW SLU campus, 815 Mercer Street
Orin Smith Auditorium, Admin Bldg. C

Breakfast Club: Tue., June 7, 2011 - Sussman

2011-05-18T14:00:00.000-07:00

Please post the attached flyer. Check the SLU Bio blog for Sussman lecture:
http://slubio.blogspot.com/2011/05/breakfast-club-tue-june-7-2011-sussman.html

To view the webcast, go to:
tcs.slu.washington.edu

The Center for Cardiovascular Biology Breakfast Club meets on Tuesday mornings under the sponsorship of the Stem Cells and Cardiovascular Repair program project grant, training grants in Cardiovascular Pathology and Cardiology, and the Mitochondria and Metabolism Center.

DISTINGUISHED LECTURE

Mark Sussman, Ph.D.Professor, SDSU Heart Institute of Bioengineering and Medicine
Department of Biology
California State University, San Diego, CA
(Faculty Host: Rong Tian, UW Mitochondria and Metabolism Center)

“Supercharging Stem Cell-mediated Regeneration”

Tuesday, June 7, 20119:00 – 10:00 a.m.
UW SLU campus, 815 Mercer Street
Brotman Auditorium (Note venue)

Breakfast Club: Tue., May 24, 2011 - Cheng

2011-05-16T14:17:00.000-07:00

VASCULATA 2011, Atlanta, GA, July 26-29

2011-05-16T13:53:00.000-07:00

SLUG Research Symposium, May 25, 2011 - Nadeau

2011-05-16T13:33:00.000-07:00

UW SLUG
RESEARCH SYMPOSIUM

May 25, 2011
11:30 a.m. – 4:00 p.m.
Administration Bldg, 1st floor

UW South Lake Union
815 Mercer St.

Keynote Speaker
2:30 – 3:30 p.m., Orin Smith Auditorium

Joseph Nadeau, Ph.D.

Director of Research and Academic Affairs &
Professor, Institute for Systems Biology
Seattle, Washington

“Persistence of Epigenetic Memories: A New Mode for Inheriting Traits and Disease”

More Info: Scott Lundy (slundy@uw.edu), Jay Gantz (gantz@u.washington.edu)

Breakfast Club: Tue., May 17, 2011 - Wight

2011-05-13T10:55:00.000-07:00

Breakfast Club: Tue., May 10, 2011 - Kim

2011-05-03T18:18:00.000-07:00

TAPAS: Thu., May 5, 2011 - Sadek

2011-04-29T13:23:00.000-07:00

SLUG presents:
Tapas

Thursday, May 5th, 2011

4:00 p.m.
Orin Smith Auditorium, Admin Bldg. C, 815 Mercer Street

Hesham Sadek, MD, PhD

Assistant Professor, Department of Internal Medicine, Division of Cardiology
University of Texas Southwestern Medical Center

"Neonatal Mouse Heart Regeneration”

Refreshments served in the lounge outside the auditorium at approximately 3:30pm

For further information on SLUG Tapas Seminars contact
Scott Lundy (slundy@uw.edu) Jay Gantz (gantz@u.washington.edu)

Special Breakfast Club: Fri., May 6, 2011 - Gibbons

2011-04-27T14:36:00.000-07:00

The Center for Cardiovascular Biology Breakfast Club meets on Tuesday mornings under the sponsorship of the Stem Cells and Cardiovascular Repair program project grant, training grants in Cardiovascular Pathology and Cardiology, and the Mitochondria and Metabolism Center.

SPECIAL BREAKFAST CLUB
REMOTE WEBCAST FROM ATLANTA

Gary H. Gibbons, M.D.

Director, Cardiovascular Research Institute
Chairman, Department of Physiology
Professor of Medicine
Morehouse School of Medicine
(Host: Steve Schwartz, UW Pathology)

“Vascular Biology and Health Disparities: Defining Molecular Pathways”

Friday, May 6, 2011

9:00 – 10:00 a.m.
UW SLU campus, 815 Mercer Street
Orin Smith Auditorium, Admin Bldg. C

Breakfast Club: Tue., May 3, 2011 - Gordon

2011-04-26T20:07:00.000-07:00

The Center for Cardiovascular Biology Breakfast Club meets on Tuesday mornings under the sponsorship of the Stem Cells and Cardiovascular Repair program project grant, training grants in Cardiovascular Pathology and Cardiology, and the Mitochondria and Metabolism Center.

Sharona E. Gordon, Ph.D.
Associate Professor
Department of Physiology and Biophysics
University of Washington
(Host: Eric Senning, UW Physiology and Biophysics)

“Regulation of TRPV1 by Phosphoinositides”

Tuesday, May 3, 2011
9:00 – 10:00 a.m.
UW SLU campus, 815 Mercer Street
Orin Smith Auditorium, Admin Bldg. C

miRNA workshop

2011-04-22T14:09:00.002-07:00

TAPAS: Thurs., Apr. 28, 2011 - Miller

2011-04-22T14:09:00.001-07:00

SLUG presents:
Tapas

Thursday, April 28th, 2011
4:00 p.m.
Orin Smith Auditorium, Admin Bldg. C, 815 Mercer Street

Dana L. Miller, PhD
Assistant Professor, Department of Biochemistry
University of Washington

"Integrated responses to hydrogen sulfide and hypoxia in C. elegans”

Refreshments served in the lounge outside the auditorium at approximately 3:30pm

For further information on SLUG Tapas Seminars contact
Scott Lundy (slundy@uw.edu) Jay Gantz (gantz@u.washington.edu)

Development of Canine ES and IPSC

2011-04-22T08:32:00.000-07:00

FHCRC Clinical Research Division Seminar

Aravind Ramakrishnan, MD

Associate in Clinical Research, FHCRC

Acting Instructor, Division of Medical Oncology, UW

Monday, April 25, 2011

Noon

FHCRC Thomas Building SZE E/W Conference Room

Video teleconferenced to: SCCA 3100/3102, UWMC 8121
CHRMC Room T3246, VAPSHCS Bldg. 24 Room 14

“Development of Canine Embryonic Stem/Induced Pluripotent Stem cell model”

Candidate for Assistant Member in Clinical Research

Monday Noon Lecture Series Objectives: Participants should develop an increased ability to critically evaluate biomedical research, recognize important new findings, and make these part of their working knowledge
CME Series Objectives: Collate and integrate current data and research findings regarding symptoms, diagnosis and treatment of cancer. Recommend and utilize appropriate cancer treatments.

The University of Washington School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

The University of Washington School of Medicine designates this educational activity for a maximum of 52.0 AMA PRA Category 1 Credits™.

Physicians should only claim credit commensurate with the extent of their participation in the activity. (Each session is 1.0 credits)

Please contact Claire Bickel in the CRD Director’s Office at 667-6815 with any questions.

Breakfast Club: Tue., April 26, 2011 - Moreno

2011-04-19T09:13:00.000-07:00

Breakfast Club: Tue., April 19, 2011: McCulloch (Distinguished Lecture)

2011-04-12T08:29:00.000-07:00

FHCRC Seminar: Tue., April 26, 2011 - Boyer

2011-04-06T15:40:00.000-07:00

CURRENT BIOLOGY SEMINAR

Title: Chromatin States and Cell Fate
Speaker: Laurie Boyer
MIT
Date: Tuesday, April 26, 2011
Time: 12:00 PM
Place: Pelton Auditorium, Weintraub Bldg., FHCRC
Sponsor: Basic Sciences Seminar Series
Bob Eisenman, 667-4445 (Admin. Carolyn x4294

TAPAS: Thurs., April 7, 2011 - Stayton

2011-04-05T13:47:00.000-07:00

SLUG presents:
Tapas

Thursday, April 7th, 2011
4:00 p.m.
Orin Smith Auditorium, Admin Bldg. C, 815 Mercer Street

Patrick S. Stayton, Ph.D.
Washington Research Foundation Professor, Department of Bioengineering
University of Washington

"Opening the Intracellular Target Universe to Biologic Drugs”

Refreshments served in the lounge outside the auditorium at approximately 3:30pm

For further information on SLUG Tapas Seminars contact
Scott Lundy (slundy@uw.edu) Jay Gantz (gantz@u.washington.edu)

Breakfast Club: Tue., Apr. 5, 2011 - Horwitz

2011-03-29T10:45:00.000-07:00

The Center for Cardiovascular Biology Breakfast Club meets on Tuesday mornings under the sponsorship of the Stem Cells and Cardiovascular Repair program project grant, training grants in Cardiovascular Pathology and Cardiology, and the Mitochondria and Metabolism Center.

Marshall Horwitz, M.D., Ph.D.
Professor, Department of Pathology
Institute for Stem Cell and Regenerative Medicine
University of Washington
(Faculty Host: Mark Majesky, Seattle Children’s Research Institute)

“Decoding cell lineage from acquired mutations using deep sequencing”

Tuesday, April 5, 2011
9:00 – 10:00 a.m.
UW SLU campus, 815 Mercer Street
Orin Smith Auditorium, Admin Bldg. C

TAPAS: Thurs., Mar. 31, 2011 - Talbot

2011-03-25T16:04:00.000-07:00

SLUG presents:
Tapas

Thursday, March 31st, 2011
4:00 p.m.
Orin Smith Auditorium, Admin Bldg. C, 815 Mercer Street

William Talbot, Ph.D.
Professor, Department of Developmental Biology
Stanford University School of Medicine

"Glial development and myelination in zebrafish”

Refreshments served in the lounge outside the auditorium at approximately 3:30pm

For further information on SLUG Tapas Seminars contact
Scott Lundy (slundy@uw.edu) Jay Gantz (gantz@u.washington.edu)

Breakfast Club: Tue., Mar. 29, 2011 - Wang

2011-03-22T13:58:00.000-07:00

To view the webcast:
For users of Mozilla Firefox, Google Chrome or other browsers, go to DimDim.com, click on “Join Meeting” and for the room name, type “Vasculata”

For users of the Internet Explorer browser, go to: https://my.dimdim.com/vasculata/

The Center for Cardiovascular Biology Breakfast Club meets on Tuesday mornings under the sponsorship of the Stem Cells and Cardiovascular Repair program project grant and training grants in Cardiovascular Pathology and Cardiology.

Ruikang K. Wang, Ph.D.

Professor, Department of Bioengineering
University of Washington
(Faculty Host: Michael Regnier, Bioengineering)

“Slicing tissue with photons: non-invasive 3D imaging of microstructure and microcirculation in tissue in vivo”

Advances in optical technologies have spurred many new applications of light in biology and medicine. The expanding fields of optical diagnostics and therapeutics include such diverse topics as photodynamic therapy for cancers and other diseases, fluorescence endoscopy for early tumor detection, photoacoustic imaging for deep tissue vascular visualization, and optical coherence tomography (OCT) for superficial tissue assessment. OCT is a new medical imaging modality in which the coherent interference of a wide spectrum light source is used to create a high resolution (micron-scale) subsurface image of tissue microstructure. Recently, we have supplemented the microstructural OCT images with additional contrast mechanisms such as blood flow imaging using the static and dynamic (Doppler) speckle effects, which provide us the ability to perform label-free optical microangiography (OMAG) of microcirculatory tissue beds. The ability to visualize tissue blood flow at the microcirculation level is important in a variety of biomedical applications, some of which (along with the OCT basics and the enabling technologies) will be highlighted in this talk. Examples using OMAG to delineate the dynamic blood perfusion, down to capillary level resolution, within living tissues will be given, including cerebral blood flow in small animals and retinal blood flow in humans.

Tuesday, March 29, 2011
9:00 – 10:00 a.m.
UW SLU campus, 815 Mercer Street
Orin Smith Auditorium, Admin Bldg. C

View

https://my.dimdim.com/viewRecording/all/vasculata/default/ecdb442c-e333-4d81-8817-824cc496e3bc/b9187ccf-6f2d-4b0c-8f17-0d0ee2695682

https://my.dimdim.com/viewChat/all/vasculata/default/ecdb442c-e333-4d81-8817-824cc496e3bc/f81f42f7-0616-4559-8ba5-052cf570f58f

Download

https://my.dimdim.com/download/recording/flv/saas/dimdim/all/vasculata/default/ecdb442c-e333-4d81-8817-824cc496e3bc/b9187ccf-6f2d-4b0c-8f17-0d0ee2695682

https://my.dimdim.com/download/recording/chat/saas/dimdim/all/vasculata/default/ecdb442c-e333-4d81-8817-824cc496e3bc/f81f42f7-0616-4559-8ba5-052cf570f58f

Special TAPAS; Mar. 22, 2011 - Bernstein

2011-03-15T11:30:00.000-07:00

CLICKHERE for answers to 5 questions about Brad's work.

SLUG presents:
Special Tapas/Breakfast Club

Tuesday, March 22nd, 2011
4:00 p.m.
Orin Smith Auditorium, Admin Bldg. C, 815 Mercer Street

Bradley Bernstein, M.D., Ph.D.
Associate Professor of Pathology, Harvard Medical School
Senior Associate Member, Broad Institute of Harvard and MIT
Early Career Scientist, Howard Hughes Medical Institute

NUCLEAR BIOLOGY: how the epigenome defines cell fate and neoplasia.

following the formal talk,residents, students, fellows & jr. Faculty invited to to stay another 30 minutes for more detailed discussion of questions arising from Brad's talk.

For further information on SLUG Tapas Seminars contact
Scott Lundy (slundy@uw.edu) Jay Gantz (gantz@u.washington.edu)

For Breakfast Club, contact JP (jparedes@uw.edu)

Bibliography of Brads papers and some relevant papers from UW authors is below.

denotes a specially recommended paper

1: Jiang H, Shukla A, Wang X, Chen WY, Bernstein BE, Roeder RG. Role for Dpy-30
in ES Cell-Fate Specification by Regulation of H3K4 Methylation within Bivalent
Domains. Cell. 2011 Feb 18;144(4):513-25. PubMed PMID: 21335234.

2: Li X, Isono K, Yamada D, Endo TA, Endoh M, Shinga J, Mizutani-Koseki Y, Otte
AP, Casanova M, Kitamura H, Kamijo T, Sharif J, Ohara O, Toyada T, Bernstein BE,
Brockdorff N, Koseki H. Mammalian polycomb-like Pcl2/Mtf2 is a novel regulatory
component of PRC2 that can differentially modulate polycomb activity both at the
Hox gene cluster and at Cdkn2a genes. Mol Cell Biol. 2011 Jan;31(2):351-64. Epub
2010 Nov 8. PubMed PMID: 21059868; PubMed Central PMCID: PMC3019975.

3: Zhou VW, Goren A, Bernstein BE. Charting histone modifications and the
functional organization of mammalian genomes. Nat Rev Genet. 2011 Jan;12(1):7-18.
Epub 2010 Nov 30. Review. PubMed PMID: 21116306.

4: Mendenhall EM, Koche RP, Truong T, Zhou VW, Issac B, Chi AS, Ku M, Bernstein
BE. GC-rich sequence elements recruit PRC2 in mammalian ES cells. PLoS Genet.
2010 Dec 9;6(12):e1001244. PubMed PMID: 21170310; PubMed Central PMCID:
PMC3000368.

5: Bernstein BE, Stamatoyannopoulos JA, Costello JF, Ren B, Milosavljevic A,
Meissner A, Kellis M, Marra MA, Beaudet AL, Ecker JR, Farnham PJ, Hirst M, Lander
ES, Mikkelsen TS, Thomson JA. The NIH Roadmap Epigenomics Mapping Consortium. Nat
Biotechnol. 2010 Oct;28(10):1045-8. PubMed PMID: 20944595.

6: Adli M, Zhu J, Bernstein BE. Genome-wide chromatin maps derived from limited
numbers of hematopoietic progenitors. Nat Methods. 2010 Aug;7(8):615-8. Epub 2010
Jul 11. PubMed PMID: 20622861; PubMed Central PMCID: PMC2924612.

7: Aiden AP, Rivera MN, Rheinbay E, Ku M, Coffman EJ, Truong TT, Vargas SO,
Lander ES, Haber DA, Bernstein BE. Wilms tumor chromatin profiles highlight stem
cell properties and a renal developmental network. Cell Stem Cell. 2010 Jun
4;6(6):591-602. PubMed PMID: 20569696; PubMed Central PMCID: PMC2897075.

8: Ozsolak F, Goren A, Gymrek M, Guttman M, Regev A, Bernstein BE, Milos PM.
Digital transcriptome profiling from attomole-level RNA samples. Genome Res. 2010
Apr;20(4):519-25. Epub 2010 Feb 4. PubMed PMID: 20133332; PubMed Central PMCID:
PMC2847755.

9: Li G, Margueron R, Ku M, Chambon P, Bernstein BE, Reinberg D. Jarid2 and PRC2,
partners in regulating gene expression. Genes Dev. 2010 Feb 15;24(4):368-80. Epub
2010 Feb 1. PubMed PMID: 20123894; PubMed Central PMCID: PMC2816736.

10: Goren A, Ozsolak F, Shoresh N, Ku M, Adli M, Hart C, Gymrek M, Zuk O, Regev
A, Milos PM, Bernstein BE. Chromatin profiling by directly sequencing small
quantities of immunoprecipitated DNA. Nat Methods. 2010 Jan;7(1):47-9. Epub 2009
Nov 29. PubMed PMID: 19946276; PubMed Central PMCID: PMC2862482.

11: Yu M, Riva L, Xie H, Schindler Y, Moran TB, Cheng Y, Yu D, Hardison R, Weiss
MJ, Orkin SH, Bernstein BE, Fraenkel E, Cantor AB. Insights into GATA-1-mediated
gene activation versus repression via genome-wide chromatin occupancy analysis.
Mol Cell. 2009 Nov 25;36(4):682-95. PubMed PMID: 19941827; PubMed Central PMCID:
PMC2800995.

12: Amit I, Garber M, Chevrier N, Leite AP, Donner Y, Eisenhaure T, Guttman M,
Grenier JK, Li W, Zuk O, Schubert LA, Birditt B, Shay T, Goren A, Zhang X, Smith
Z, Deering R, McDonald RC, Cabili M, Bernstein BE, Rinn JL, Meissner A, Root DE,
Hacohen N, Regev A. Unbiased reconstruction of a mammalian transcriptional
network mediating pathogen responses. Science. 2009 Oct 9;326(5950):257-63. Epub
2009 Sep 3. PubMed PMID: 19729616; PubMed Central PMCID: PMC2879337.

13: Khalil AM, Guttman M, Huarte M, Garber M, Raj A, Rivea Morales D, Thomas K,
Presser A, Bernstein BE, van Oudenaarden A, Regev A, Lander ES, Rinn JL. Many
human large intergenic noncoding RNAs associate with chromatin-modifying
complexes and affect gene expression. Proc Natl Acad Sci U S A. 2009 Jul
14;106(28):11667-72. Epub 2009 Jul 1. PubMed PMID: 19571010; PubMed Central
PMCID: PMC2704857.

14: Guttman M, Amit I, Garber M, French C, Lin MF, Feldser D, Huarte M, Zuk O,
Carey BW, Cassady JP, Cabili MN, Jaenisch R, Mikkelsen TS, Jacks T, Hacohen N,
Bernstein BE, Kellis M, Regev A, Rinn JL, Lander ES. Chromatin signature reveals
over a thousand highly conserved large non-coding RNAs in mammals. Nature. 2009
Mar 12;458(7235):223-7. Epub 2009 Feb 1. PubMed PMID: 19182780; PubMed Central
PMCID: PMC2754849.

15: Chi AS, Bernstein BE. Developmental biology. Pluripotent chromatin state.
Science. 2009 Jan 9;323(5911):220-1. PubMed PMID: 19131621.

16: Ku M, Koche RP, Rheinbay E, Mendenhall EM, Endoh M, Mikkelsen TS, Presser A,
Nusbaum C, Xie X, Chi AS, Adli M, Kasif S, Ptaszek LM, Cowan CA, Lander ES,
Koseki H, Bernstein BE. Genomewide analysis of PRC1 and PRC2 occupancy identifies
two classes of bivalent domains. PLoS Genet. 2008 Oct;4(10):e1000242. Epub 2008
Oct 31. PubMed PMID: 18974828; PubMed Central PMCID: PMC2567431.

John Stamatoyannopoulos

1: Kaplan T, Li XY, Sabo PJ, Thomas S, Stamatoyannopoulos JA, Biggin MD, Eisen
MB. Quantitative models of the mechanisms that control genome-wide patterns of
transcription factor binding during early Drosophila development. PLoS Genet.
2011 Feb 3;7(2):e1001290. PubMed PMID: 21304941; PubMed Central PMCID:
PMC3033374.

2: Casadei S, Norquist BM, Walsh T, Stray SM, Mandell JB, Lee MK,
Stamatoyannopoulos JA, King MC. Contribution to Familial Breast Cancer of
Inherited Mutations in the BRCA2-interacting Protein PALB2. Cancer Res. 2011 Feb
1. [Epub ahead of print] PubMed PMID: 21285249.

3: John S, Sabo PJ, Thurman RE, Sung MH, Biddie SC, Johnson TA, Hager GL,
Stamatoyannopoulos JA. Chromatin accessibility pre-determines glucocorticoid
receptor binding patterns. Nat Genet. 2011 Mar;43(3):264-8. Epub 2011 Jan 23.
PubMed PMID: 21258342.

4: Kharchenko PV, Alekseyenko AA, Schwartz YB, Minoda A, Riddle NC, Ernst J, Sabo
PJ, Larschan E, Gorchakov AA, Gu T, Linder-Basso D, Plachetka A, Shanower G,
Tolstorukov MY, Luquette LJ, Xi R, Jung YL, Park RW, Bishop EP, Canfield TP,
Sandstrom R, Thurman RE, Macalpine DM, Stamatoyannopoulos JA, Kellis M, Elgin SC,
Kuroda MI, Pirrotta V, Karpen GH, Park PJ. Comprehensive analysis of the
chromatin landscape in Drosophila melanogaster. Nature. 2010 Dec 22. [Epub ahead
of print] PubMed PMID: 21179089.

5: Bernstein BE, Stamatoyannopoulos JA, Costello JF, Ren B, Milosavljevic A,
Meissner A, Kellis M, Marra MA, Beaudet AL, Ecker JR, Farnham PJ, Hirst M, Lander
ES, Mikkelsen TS, Thomson JA. The NIH Roadmap Epigenomics Mapping Consortium. Nat
Biotechnol. 2010 Oct;28(10):1045-8. PubMed PMID: 20944595.

6: Stamatoyannopoulos JA. Illuminating eukaryotic transcription start sites. Nat
Methods. 2010 Jul;7(7):501-3. PubMed PMID: 20588267.

7: Gheldof N, Smith EM, Tabuchi TM, Koch CM, Dunham I, Stamatoyannopoulos JA,
Dekker J. Cell-type-specific long-range looping interactions identify distant
regulatory elements of the CFTR gene. Nucleic Acids Res. 2010 Jul;38(13):4325-36.
Epub 2010 Mar 31. PubMed PMID: 20360044; PubMed Central PMCID: PMC2910055.

8: Miller BG, Stamatoyannopoulos JA. Integrative meta-analysis of differential
gene expression in acute myeloid leukemia. PLoS One. 2010 Mar 1;5(3):e9466.
PubMed PMID: 20209125; PubMed Central PMCID: PMC2830886.

9: Hansen RS, Thomas S, Sandstrom R, Canfield TK, Thurman RE, Weaver M, Dorschner
MO, Gartler SM, Stamatoyannopoulos JA. Sequencing newly replicated DNA reveals
widespread plasticity in human replication timing. Proc Natl Acad Sci U S A. 2010
Jan 5;107(1):139-44. Epub 2009 Dec 4. PubMed PMID: 19966280; PubMed Central
PMCID: PMC2806781.

10: Hesselberth JR, Chen X, Zhang Z, Sabo PJ, Sandstrom R, Reynolds AP, Thurman
RE, Neph S, Kuehn MS, Noble WS, Fields S, Stamatoyannopoulos JA. Global mapping
of protein-DNA interactions in vivo by digital genomic footprinting. Nat Methods.
2009 Apr;6(4):283-9. Epub 2009 Mar 22. PubMed PMID: 19305407; PubMed Central
PMCID: PMC2668528.

11: Attanasio C, Reymond A, Humbert R, Lyle R, Kuehn MS, Neph S, Sabo PJ, Goldy
J, Weaver M, Haydock A, Lee K, Dorschner M, Dermitzakis ET, Antonarakis SE,
Stamatoyannopoulos JA. Assaying the regulatory potential of mammalian conserved
non-coding sequences in human cells. Genome Biol. 2008;9(12):R168. Epub 2008 Dec
2. PubMed PMID: 19055709; PubMed Central PMCID: PMC2646272.

Tony Blau

1: Duan Z, Andronescu M, Schutz K, McIlwain S, Kim YJ, Lee C, Shendure J, Fields
S, Blau CA, Noble WS. A three-dimensional model of the yeast genome. Nature. 2010
May 20;465(7296):363-7. Epub 2010 May 2. PubMed PMID: 20436457; PubMed Central
PMCID: PMC2874121.

2: Stadler B, Ivanovska I, Mehta K, Song S, Nelson A, Tan Y, Mathieu J, Darby C,
Blau CA, Ware C, Peters G, Miller DG, Shen L, Cleary MA, Ruohola-Baker H.
Characterization of microRNAs involved in embryonic stem cell states. Stem Cells
Dev. 2010 Jul;19(7):935-50. PubMed PMID: 20128659.

3: Ware CB, Wang L, Mecham BH, Shen L, Nelson AM, Bar M, Lamba DA, Dauphin DS,
Buckingham B, Askari B, Lim R, Tewari M, Gartler SM, Issa JP, Pavlidis P, Duan Z,
Blau CA. Histone deacetylase inhibition elicits an evolutionarily conserved
self-renewal program in embryonic stem cells. Cell Stem Cell. 2009 Apr
3;4(4):359-69. PubMed PMID: 19341625; PubMed Central PMCID: PMC2719860.

4: Lin EH, Jiang Y, Deng Y, Lapsiwala R, Lin T, Blau CA. Cancer stem cells,
endothelial progenitors, and mesenchymal stem cells: "seed and soil" theory
revisited. Gastrointest Cancer Res. 2008 Jul;2(4):169-74. PubMed PMID: 19259284;
PubMed Central PMCID: PMC2632830.

Lee SI

1: Gentles AJ, Alizadeh AA, Lee SI, Myklebust JH, Shachaf CM, Shahbaba B, Levy R,
Koller D, Plevritis SK. A pluripotency signature predicts histologic
transformation and influences survival in follicular lymphoma patients. Blood.
2009 Oct 8;114(15):3158-66. Epub 2009 Jul 27. PubMed PMID: 19636063; PubMed
Central PMCID: PMC2759646.

2: Lee SI, Dudley AM, Drubin D, Silver PA, Krogan NJ, Pe'er D, Koller D. Learning
a prior on regulatory potential from eQTL data. PLoS Genet. 2009
Jan;5(1):e1000358. Epub 2009 Jan 30. PubMed PMID: 19180192; PubMed Central PMCID:
PMC2627940.

3: Lee SI, Pe'er D, Dudley AM, Church GM, Koller D. Identifying regulatory
mechanisms using individual variation reveals key role for chromatin
modification. Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):14062-7. Epub 2006
Sep 12. PubMed PMID: 16968785; PubMed Central PMCID: PMC1599912.

4: Hillenmeyer ME, Fung E, Wildenhain J, Pierce SE, Hoon S, Lee W, Proctor M, St
Onge RP, Tyers M, Koller D, Altman RB, Davis RW, Nislow C, Giaever G. The
chemical genomic portrait of yeast: uncovering a phenotype for all genes.
Science. 2008 Apr 18;320(5874):362-5. PubMed PMID: 18420932; PubMed Central
PMCID: PMC2794835.

Breakfast Club: Tue., March 22, 2011 - Tardiff

2011-03-11T15:06:00.000-08:00

The Center for Cardiovascular Biology Breakfast Club meets on Tuesday mornings under the sponsorship of the Stem Cells and Cardiovascular Repair program project grant and training grants in Cardiovascular Pathology and Cardiology.

DISTINGUISHED LECTURE

Jil C. Tardiff, M.D., Ph.D.Associate Professor of Physiology and Biophysics
Associate Professor of Internal Medicine (Adult Cardiology)
Albert Einstein College of Medicine, Bronx, New York
(Faculty Host: Michael Regnier, UW Bioengineering)

“Thin-Filament Related Cardiomyopathies: An Integrative Approach to a Complex Disorder”

Tuesday, March 22, 2011
9:00 – 10:00 a.m.
UW SLU campus, 815 Mercer Street
Orin Smith Auditorium, Admin Bldg. C

TAPAS: Thurs., Mar. 17, 2011 - Ornitz

2011-03-11T14:59:00.000-08:00

SLUG presents:
Tapas

Thursday, March 17th, 2011
3:00 p.m. (Note time change)

Orin Smith Auditorium, Admin Bldg. C, 815 Mercer Street

David Ornitz, M.D., Ph.D.
Professor, Department of Developmental Biology
Washington University in St. Louis

"Fibroblast Growth Factor Signaling Pathways in Lung Development and Cancer"

Refreshments served in the lounge outside the auditorium at approximately 2:30pm

For further information on SLUG Tapas Seminars contact
Scott Lundy (slundy@uw.edu)
Jay Gantz (gantz@u.washington.edu)

Breakfast Club: Tue., Mar. 15, 2011 - Rabinovitch

2011-03-02T13:52:00.000-08:00

The Center for Cardiovascular Biology Breakfast Club meets on Tuesday mornings under the sponsorship of the Stem Cells and Cardiovascular Repair program project grant and training grants in Cardiovascular Pathology and Cardiology.

Marlene Rabinovitch, M.D.
Dwight and Vera Dunlevie Professor of Pediatric Cardiology
Stanford University School of Medicine
(Faculty Host: Bill Parks, Center for Lung Biology)

PFIZER VISITING PROFESSORSHIP IN
PULMONARY VASCULAR DISEASE

“The Sequelae of Dysfunctional BMPRII Signaling”

Tuesday, March 15, 2011
9:00 – 10:00 a.m.
UW SLU campus, 815 Mercer Street
Orin Smith Auditorium, Admin Bldg. C

Breakfast Club: Tue., Mar. 8, 2011 - Moussavi-Harami

2011-02-28T14:26:00.000-08:00

Mitochondrial Moelcular Biology

2011-02-25T11:14:00.001-08:00

Matthew Bobiak

Stony Brook University

Direct Repair of the Human Mitochondrial

Genome by AlkB Homologue 7

Monday, March 7, 2011

11:00 am

Arnold Building

FHCRC Campus

M4-A805/A817

Breakfast Club: Tue., Mar. 1, 2011 - Duan

2011-02-22T11:21:00.000-08:00

Interactive Video on Scientific Misconduct.

2011-02-18T10:40:00.000-08:00

Ed. The issue of scientific misconduct is a hot one at the UW because of the unilateral action of the President to fire Professor Aprikyan despite the universal finding by a Senate panel that the UW had not followed due process. Read more here.

The Lab is an interactive video from the NIH Office of Research Integrity.

The intent of the video is to train faculty, fellows ans staff in how to avoid charges of research misconduct, including what to do if you feel such misconduct has occurred or if you are charged with misconduct.

The video lets you become the lead characters in an interactive movie and make decisions about integrity in research that can have long-term consequences. The simulation addresses Responsible Conduct of Research topics such as avoiding research misconduct, mentorship responsibilities, handling of data, responsible authorship, and questionable research practices.

The Characters

You assume the role of four characters confronted with the pressures of working in a research laboratory:

KIM PARK, a third-year graduate student, who questions the use of her data by another researcher.

HARDIK RAO, a postdoctoral student, who deals with the competitiveness in an up-and-coming lab while balancing the responsibilities of a home life.

AARON HUTCHINS, a principal investigator, whose overwhelming responsibilities as a professor, researcher, and grantwriter lead to his decline as a responsible mentor.

BETH RIDGELY, a research administrator, who has accepted the role as the university�s Research Integrity Officer and must quickly learn how to handle allegations of research misconduct.

Breakfast Club: Tue., Feb. 22, 2011 - Faber

2011-02-02T12:24:00.000-08:00

This is a WEBCAST lecture from North Carolina

To view the webcast:
For users of Mozilla Firefox, Google Chrome or other browsers, go to DimDim.com, click on “Join Meeting” and for the room name, type “Vasculata”

For users of the Internet Explorer browser, go to: https://my.dimdim.com/vasculata/

The Center for Cardiovascular Biology Breakfast Club meets on Tuesday mornings under the sponsorship of the Stem Cells and Cardiovascular Repair program project grant and training grants in Cardiovascular Pathology and Cardiology.

James E. Faber, Ph.D.
Professor
Department of Cell and Molecular Physiology
McAllister Heart Institute
University of North Carolina at Chapel Hill
(Faculty Host: Steve Schwartz, Pathology)

“The native collateral circulation: Genetic and environmental determinants.”

Tuesday, February 22, 20119:00 – 10:00 a.m.
UW SLU campus, 815 Mercer Street
Orin Smith Auditorium, Admin Bldg. C

TAPAS: Thu., Feb. 17, 2011 - Sampath

2011-02-02T12:17:00.000-08:00

SLUG presents:
Tapas

Thursday, February 17th, 2011
4:00 p.m.
Orin Smith Auditorium, Admin Bldg. C, 815 Mercer Street

Prabha Sampath, Ph.D.
Principal Investigator
Institute of Medical Biology
Agency for Science, Technology and Research (A*Star)
Singapore

"Targeting Glioblastoma Stem Cells by Sequence-specific Functional Inhibition of a Pro-survival OncomiR”

Refreshments served in the lounge outside the auditorium at approximately 3:30pm

For further information on SLUG Tapas Seminars contact
Scott Lundy (slundy@uw.edu)
Jay Gantz (gantz@u.washington.edu)

Breakfast Club: Tue., Feb. 15, 2011 - Dale Abel

2011-02-01T11:31:00.000-08:00

This lecture will be webcast but not recorded/archived.

To view the webcast:
For users of Mozilla Firefox, Google Chrome or other browsers, go to DimDim.com, click on “Join Meeting” and for the room name, type “Vasculata”

For users of the Internet Explorer browser, go to: https://my.dimdim.com/vasculata/

The Center for Cardiovascular Biology Breakfast Club meets on Tuesday mornings under the sponsorship of the Stem Cells and Cardiovascular Repair program project grant and training grants in Cardiovascular Pathology and Cardiology.

DISTINGUISHED LECTURE

E. Dale Abel, MD, D Phil
Professor of Medicine and Biochemistry
Chief, Division of Endocrinology, Metabolism and Diabetes
University of Utah School of Medicine
(Faculty Host: Rong Tian, UW Mitochondria and Metabolism Center)

“Insulin Resistance and Cardiovascular Dysfunction – Elucidating Novel Mechanisms”

Tuesday, February 15, 2011
9:00 – 10:00 a.m.
UW SLU campus, 815 Mercer Street
Orin Smith Auditorium, Admin Bldg. C

Dr. Abel is a world expert in the regulation of myocardial biology and metabolism by insulin signaling. His work in the last decade has significantly advanced our knowledge of disease mechanisms for the cardiomyopathy caused by metabolic disorders.

Representative publications:
1. Cardiac remodeling in obesity. Physiol Rev. 2008 Apr;88(2):389-419
2. A conserved role for phosphatidylinositol 3-kinase but not Akt signaling in mitochondrial adaptations that accompany physiological cardiac hypertrophy. Cell Metab. 2007 Oct;6(4):294-306

Breakfast Club: Tue., Feb. 8, 2011 - Kron

2011-01-27T12:40:00.001-08:00

This lecture will NOT be webcast. PLEASE NOTE THE VENUE.

The Center for Cardiovascular Biology Breakfast Club meets on Tuesday mornings under the sponsorship of the Stem Cells and Cardiovascular Repair program project grant and training grants in Cardiovascular Pathology and Cardiology.

Stephen Kron M.D., Ph.D.
Ludwig Center for Metastasis Research
The University of Chicago
(Faculty host: Charles E. Murry, Pathology & Bioengineering)

“Targeting chromatin to accelerate tumor cell senescence”
(Faculty Host: Charles E. Murry, Pathology & Bioengineering)

Tuesday, February 8, 2011
9:00 – 10:00 a.m.
UW SLU campus, 815 Mercer Street
Brotman Auditorium

Breakfast Club: Tue., Feb. 1, 2011: Morris

2011-01-24T13:21:00.000-08:00

TAPAS: Thu., Feb. 3, 2011: Ingwall

2011-01-24T12:34:00.001-08:00

SLUG presents:
Tapas

Thursday, February 3rd, 2011
4:00 p.m.
Orin Smith Auditorium, Admin Bldg. C, 815 Mercer Street

Joanne S. Ingwall, Ph.D.
Professor of Medicine (Physiology)
Brigham and Women's Hospital
Boston, Massachusetts

"On mentoring: An essential tool for academic success”

Refreshments served in the lounge outside the auditorium at approximately 3:30pm

For further information on SLUG Tapas Seminars contact
Scott Lundy (slundy@uw.edu)
Jay Gantz (gantz@u.washington.edu)

2011-01-18T12:39:00.000-08:00

SLUG presents:
Tapas

Thursday, January 20th, 2011
4:00 p.m.
Orin Smith Auditorium, Admin Bldg. C, 815 Mercer Street

Deepak Srivastava, M.D.
Director, Gladstone Institute of Cardiovascular Disease
Professor, Departments of Pediatrics, and Biochemistry & Biophysics
Wilma and Adeline Pirag Distinguished Professor in Pediatric Developmental Cardiology
University of California, San Francisco

"Reprogramming Approaches to Cardiovascular Disease”

Refreshments served in the lounge outside the auditorium at approximately 3:30pm

For further information on SLUG Tapas Seminars contact
Scott Lundy (slundy@uw.edu)
Jay Gantz (gantz@u.washington.edu)

Breakfast Club: Tue., Jan. 25, 2011 - Thomas Force

2011-01-18T10:36:00.000-08:00

Please post the attached flyer.

This talk will NOT be webcast

The Center for Cardiovascular Biology Breakfast Club meets on Tuesday mornings under the sponsorship of the Stem Cells and Cardiovascular Repair program project grant and training grants in Cardiovascular Pathology and Cardiology.

Thomas Force, MD
James C. Wilson Professor of Medicine
Clinical Director, Center for Translational Medicine
Thomas Jefferson University
(Host: Rong Tian, Mitochondria and Metabolism Center)

“Novel regulators of ischemic injury and ventricular remodeling”

Tuesday, January 25, 2011
9:00 – 10:00 a.m.
UW SLU campus, 815 Mercer Street
Orin Smith Auditorium, Admin Bldg. C

Dr. Force is a recognized leader in stress-induced signaling cascades in cardiac growth and survival. His lab has pioneered research on the cardiotoxicity caused by tyrosine kinase inhibitor cancer therapeutics. His recent work has elucidated the isoform-specific role of GSK-3 in cardiac hypertrophy.

Representative publications:
1. GSK-3alpha directly regulates beta-adrenergic signaling and the response of the heart to hemodynamic stress in mice. J Clin Invest. 2010
2. Serine 58 of 14-3-3zeta is a molecular switch regulating ASK1 and oxidant stress-induced cell death. Mol Cell Biol. 2009
3. Cardiotoxicity of the cancer therapeutic agent imatinib mesylate. Nat Med. 2006

Breakfast Club: Tue., Jan. 18, 2011: Luke Timmerman

2011-01-06T14:45:00.000-08:00

Please post the attached flyer.

To view the webcast:
Go to DimDim.com, click on “Join Meeting” and for the room name, type “Vasculata”

The Center for Cardiovascular Biology Breakfast Club meets on Tuesday mornings under the sponsorship of the Stem Cells and Cardiovascular Repair program project grant and training grants in Cardiovascular Pathology and Cardiology.

Luke Timmerman
National Biotechnology Editor
Xconomy

“The State of Seattle Biotech in 2011”

Tuesday, January 18, 2011
9:00 – 10:00 a.m.
UW SLU campus, 815 Mercer Street
Orin Smith Auditorium, Admin Bldg. C

TAPAS: Thu., Jan. 13, 2011: Moritz

2011-01-05T13:38:00.000-08:00

SLUG presents:
Tapas

Thursday, January 13th, 2011
4:00 p.m.
Orin Smith Auditorium, Admin Bldg. C, 815 Mercer Street

Chet T Moritz, PhD, MD
Assistant Professor
Departments of Rehabilitation Medicine
and Physiology & Biophysics
University of Washington School of Medicine

"Promoting neural plasticity for the treatment of movement disorders”

Refreshments served in the lounge outside the auditorium at approximately 3:30pm

For further information on SLUG Tapas Seminars contact
Scott Lundy (slundy@uw.edu)
Jay Gantz (gantz@u.washington.edu)

Breakfast Club: Tues., Jan. 11, 2011: Study Section

2011-01-05T12:57:00.000-08:00

To view the webcast:
Go to DimDim.com, click on “Join Meeting” and for the room name, type “Vasculata”

The Center for Cardiovascular Biology Breakfast Club meets on Tuesday mornings under the sponsorship of the Stem Cells and Cardiovascular Repair program project grant and training grants in Cardiovascular Pathology and Cardiology.

Michael E. Rosenfeld, PhD
Professor, Environmental & Occupational Health Sciences; Professor, Pathology
Chair, ATHEROSCLEROSIS AND INFLAMMATION OF THE CARDIOVASCULAR SYSTEM STUDY SECTION

Karin Bornfeldt, PhD
Professor, Pathology, Diabetes and Obesity Center of Excellence
Member, CARDIOVASCULAR BIOLOGY AND THE COMPLICATIONS OF DIABETES STUDY SECTION

William Parks, PhD
Professor, Center for Lung Biology
Chair, LUNG INJURY, REPAIR, AND REMODELING (LIRR) STUDY SECTION

Jay Heinecke, MD
Professor, Division of Metabolism, Endocrinology and Nutrition
Member, INTEGRATIVE NUTRITION AND METABOLIC PROCESSES STUDY SECTION

"Enhanced peer review of NIH grant proposals: how the process is supposed to work but often doesn't.”
A panel discussion with current members of NIH study sections and review groups

Tuesday, January 11, 2011
9:00 – 10:00 a.m.
UW SLU campus, 815 Mercer Street
Orin Smith Auditorium, Admin Bldg. C

View recordings at: Study Section talk

Breakfast Club: Winter 2011 schedule

2011-01-03T13:25:00.000-08:00

January 4 - Tomas Vaisar (Host: David Dichek)

January 11 - Study section (Mike Rosenfeld, Karin Bornfeldt, William Parks, Jay Heinecke)

January 18 - Luke Timmerman (Host: David Dichek)

January 25(DL) - Thomas Force, MD (Host: Rong Tian) NO WEBCAST

February 1 - Dan Morris (Host: Rong Tian)

February 8 - Web lecture (Brotman Auditorium) Speaker TBA

February 15(DL) - Dale Abel (Host: Rong Tian)

February 22 - Deok-Ho Kim (Host: Steve Schwartz)

March 1 - Zhi-jun Duan (Host: Steve Schwartz)

March 8 - Farid Moussavi-Harami (Host: Mike Chin)

March 15 - Marlene Rabinovitch (Host: Bill Parks)

March 22(DL) - Jill Tardiff (Host: Mike Regnier)

March 29 - RK Wang (Host: David Dichek)

Note: DL = Distinguished lecture

Unless otherwise indicated, lectures will be held at the Orin Smith Auditorium, UW South Lake Union campus and will be webcast via dimdim.com. To access the webcast, type in "Vasculata" to join the meeting room. Webcast may be subject to change to no webcast upon request by the speaker. We will update the notices accordingly.

Breakfast Club: Tuesday, Jan. 4, 2011: Tomas Vaisar

2010-12-29T11:47:00.000-08:00

The Center for Cardiovascular Biology Breakfast Club meets on Tuesday mornings under the sponsorship of the Stem Cells and Cardiovascular Repair program project grant and training grants in Cardiovascular Pathology and Cardiology.

Tomas Vaisar, PhD

Research Assistant Professor
Department of Medicine
Division of Metabolism, Endocrinology and Nutrition
University of Washington

“HDL, inflammation, and atherosclerosis. A paradigm shift?”

Tuesday, January 4, 2011

9:00 – 10:00 a.m.
UW SLU campus, 815 Mercer Street
Orin Smith Auditorium, Admin Bldg. C

Path Presents: Swanson, Jan. 26, 2011, 4:30 pm, UW K-069

2010-12-28T12:05:00.001-08:00

Kristin Swanson, Ph.D.
Associate Research Professor, UW Medicine Pathology
Affiliate Investigator of Computational Biology, Fred Hutchinson Cancer Research Center

Patient-Specific Mathematical Neuro-Oncology: A Paradigm Shift in Glioma Treatment

Wednesday, January 26, 2011 at 4:30 PM
Health Sciences Center
Room K-069

Faculty Host: Tom Montine, M.D., Ph.D.

Why Attend?
Gliomas are complex heterogeneous tumors with a spectrum of behaviors with an overall dismal prognosis. The relative low incidence and the wide variability of this disease across (and within) patients is a challenge to routine clinical studies to determine optimal treatment strategies. This heterogeneity suggests a patient-specific quantification of disease kinetics and treatment response is essential to improving outcomes for these patients. This seminar will discuss the role of the burgeoning field of Mathematical NeuroOncology specifically focusing on the practical application of patient-specific mathematical modeling approaches in providing predictive insight into tumor growth kinetics and response to therapy in individual patients.

Path Presents: Grady, Jan. 19, 2011, 4:30 pm, UW K-069

2010-12-28T12:03:00.000-08:00

William Grady, M.D.
Rodger C. Haggitt Associate Professor, University of Washington School of Medicine
Associate Member, Fred Hutchinson Cancer Research Center

The Cooperation of Epigenetic and Genetic Alterations in Gastrointestinal Cancer

Wednesday, January 19, 2011 at 4:30 PM
Health Sciences Center
Room K-069

Faculty Host: Matthew Yeh, M.D., Ph.D.

Why Attend?
Dr. Grady will discuss the role of genetic alterations and epigenetic alterations that occur in colon cancer on the behavior of the cancer cells. In particular, an understanding of signal network deregulation and gene cooperation will be gained from attending this lecture.

Path Presents: Yee, Jan. 12, 2011, 4:30 pm, UW K-069

2010-12-28T12:00:00.000-08:00

Cassian Yee, M.D.
Professor, UW Medicine Oncology
Member, Clinical Research Division, Fred Hutchinson Cancer Research Center

T Cell Therapy of Cancer

Wednesday, January 12, 2011 at 4:30 PM
Health Sciences Center
Room K-069

Faculty Host: Kim Allison, M.D.

Why Attend?
A Renaissance in immunotherapy or another passing fad? My NIH reviewers want to know. Find out what I told them and where the field is headed.

Path Presents, Palmiter, Jan. 5, 2011, 4:30 pm, UW K-069

2010-12-28T11:55:00.000-08:00

Richard Palmiter, Ph.D.
Professor, UW Medicine Biochemistry
Investigator, Howard Hughes Medical Institute

Mouse Model of Leigh Syndrome: Identifying Critical Brain Regions Involved

Wednesday, January 5, 2011 at 4:30 PM
Health Sciences Center
Room K-069

Faculty Host: Tom Montine, M.D., Ph.D.

Why Attend?
Leigh syndrome is a necrotizing encephalopathy caused by mitochondrial dysfunction due to mutations in either mitochondrial or nuclear genes involved in electron transport. We have created a mouse with a mutation in Ndufs4, one of the 45 subunits of complex 1, the recapitulates virtually all of the symptoms of Leigh syndrome. We have shown that the disease is caused by mitochondrial dysfunction in the central nervous system and that it results in progressive gliosis, and eventually neuronal loss, in the olfactory bulb, vestibular nucleus and cerebellum. The knockout mice have breathing defects that may be responsible for their demise by about 50 days after birth. Selective inactivation of Ndufs4 in the vestibular nucleus results in premature death, whereas selective restoration of Ndufs4 in the vestibular nucleus prolongs life.

Breakfast Club: Tue., Dec. 14, 2010: Liao

2010-12-08T14:37:00.001-08:00

NOTE: This lecture will not be webcast

The Center for Cardiovascular Biology Breakfast Club meets on Tuesday mornings under the sponsorship of the Stem Cells and Cardiovascular Repair program project grant and training grants in Cardiovascular Pathology and Cardiology.

DISTINGUISHED LECTURE SERIES

Ronglih Liao, PhD
Associate Professor of Medicine
Harvard Medical School

“Adult stem cells for cardiac repair and regeneration: In it to WNT”

Tuesday, December 14, 2010
9:00 – 10:00 a.m.
UW SLU campus, 815 Mercer Street
Orin Smith Auditorium, Admin Bldg. C

Dr. Liao is Associate Professor of Medicine at Harvard Medical School. She leads the research in adult cardiac stem cell biology and cardiac repair. Work from her laboratory in the past decade has substantially advanced our knowledge of the cardiac SP cells.

Breakfast Club: Tue., Dec. 7, 2010: Hannele Ruohola-Baker

2010-11-30T13:33:00.000-08:00

SLU 14T MRI Mini-Symposium, Dec. 16, 2011

2010-11-24T16:15:00.000-08:00

South Lake Union 14T MRI Mini-Symposium
Date: Thursday, December 16, 2010
Time: 2:30 to 6:00 pm
Location: Brotman Auditorium, South Lake Union

A high-field 14T NMR scanner was installed at SLU to support various
on-going and future research projects. This mini-symposium will provide
opportunities to see potentials of the device and to talk with investigators
and technical experts.

Introductory Comments by Norman J. Beauchamp, Jr., M.D., M.P.H.; Debra A.
Schwinn, M.D.; and David L. Eaton, Ph.D.

The keynote speaker is Martin J. Kushmerick, M.D., Ph.D., Radiology.

There will be sessions on spectroscopy, imaging and technical development.
The will be a reception from 5:30- 6:00 pm

Breakfast Club: Tuesday, Nov. 30, 2010: Rachel Klevit

2010-11-22T13:34:00.000-08:00

To view the webcast:
Go to DimDim.com, click on “Join Meeting” and for the room name, type “Vasculata”

The Center for Cardiovascular Biology Breakfast Club meets on Tuesday mornings under the sponsorship of the Stem Cells and Cardiovascular Repair program project grant and training grants in Cardiovascular Pathology and Cardiology.

(Note the venue)

Rachel E. Klevit, D. Phil.
Professor of Biochemistry
University of Washington

“Taming the Beast: Structural biology of alphaB-crystallin, a small heat shock protein implicated in cardiomyopathy”

Tuesday, November 30, 2010
9:00 – 10:00 a.m.
UW SLU campus, 815 Mercer Street
Brotman Auditorium

To view the talk:
https://my.dimdim.com/viewRecording/all/vasculata/default/96e9c1cc-4571-4742-8bd0-fed3a7bcf6f6/787c9614-b02e-4394-a7c8-3c00e5229b91

To download teh talk:
https://my.dimdim.com/download/recording/flv/saas/dimdim/all/vasculata/default/96e9c1cc-4571-4742-8bd0-fed3a7bcf6f6/787c9614-b02e-4394-a7c8-3c00e5229b91

Breakfast Club: Tue., Nov. 23, 2010: J. Lee Nelson

2010-11-16T11:30:00.000-08:00

The Center for Cardiovascular Biology Breakfast Club meets on Tuesday mornings under the sponsorship of the Stem Cells and Cardiovascular Repair program project grant and training grants in Cardiovascular Pathology and Cardiology.

J. Lee Nelson, MD

Member, Fred Hutchinson Cancer Research Center
Professor, Rheumatology, University of Washington

“Microchimerism: For better or
for worse?”

Tuesday, November 23, 2010
9:00 – 10:00 a.m.
UW SLU campus, 815 Mercer Street
Orin Smith Auditorium, Admin Bldg. C

To view the webcast:
Go to DimDim.com, click on “Join Meeting” and for the room name, type “Vasculata”

Medical Genetics seminar: Friday, Nov. 19: Morgan and Sedensky

2010-11-15T14:14:00.000-08:00

Friday, November 19, 12:30-1:30 PM
HSB K069

Division of Medical Genetics presents...:

Phil Morgan, M.D.
Professor, Anesthesiology & Pain Medicine

Margaret Sedensky, M.D.
Professor, Anesthesiology & Pain Medicine

“C. elegans as a model for mitochondrial disease.”

To be added to the mailing list, send an email message to: medgen@u.washington.edu. To request disability accommodations, contact the Office of the ADA Coordinator at least 10 days in advance. 206-543-6450(voice); 206-543-6252(TDD); 206-685-3885(fax) access@u.washington.edu

Breakfast Club: Tue., Nov. 16, 2010: Angie Hertz

2010-11-12T10:25:00.000-08:00

NOTE the different time and venue for this lecture.

The Breakfast Club encourages comments about the talks. These may be made by going to our blog (http://slubio.blogspot.com/) and making comments below the seminar announcement. We will encourage the speaker or others to reply.

To view the webcast:
Go to DimDim.com, click on “Join Meeting” and for the room name, type “Vasculata”

The Center for Cardiovascular Biology Breakfast Club meets on Tuesday mornings under the sponsorship of the Stem Cells and Cardiovascular Repair program project grant and training grants in Cardiovascular Pathology and Cardiology.

Angie L. Hertz
Predoctoral Research Associate
Department of Pharmacology (Beavo Lab)
University of Washington

“The role of phosphodiesterases in inflammation”

Tuesday, November 16, 2010
8:30 – 9:30 a.m.
UW SLU campus, 815 Mercer Street
Brotman Auditorium

NOTE the different time and venue for this lecture.

To view the webcast:

View https://my.dimdim.com/viewRecording/all/vasculata/default/d732f51c-bfbc-40d0-92bd-7c605c80b495/2f5f7943-66a1-4b38-8637-494497cffd9b

Download https://my.dimdim.com/download/recording/flv/saas/dimdim/all/vasculata/default/d732f51c-bfbc-40d0-92bd-7c605c80b495/2f5f7943-66a1-4b38-8637-494497cffd9b

Important paper, lymphatic deve requires arteries

2010-11-12T07:49:00.000-08:00

Important paper, lymphatic deve requires arteries

Arteries provide essential guidance cues for lymphatic endothelial cells in the zebrafish trunk

Bussmann J, Bos F, Duckers H, Schulte-Merker S

Development. 2010; 137

Abstract | Full Text | Related Articles | Citations on Google Scholar | Order Article

SCRI Center for Developmental Therapeutics lecture, Nov. 10, 2010: Sihem Boudina

2010-11-05T12:51:00.000-07:00

Seattle Children’s Research Institute
Center for Developmental Therapeutics
Guest Speaker

Sihem Boudina, PhD
Assistant Professor
Center on Aging
University of Utah

“Is Insulin Resistance Bad or Good for your Heart?”

A common feature of type 2 diabetes is insulin resistance in peripheral tissues like the heart. We utilize mouse models with cardiac-specific insulin receptors deletion to investigate the role of insulin signaling in cardiac physiology and aging.

Wednesday, November 10, 2010
12:00 PM
Building 1, Large Conference Room 506

Our Center welcomes you to enjoy our guest’s presentation on 5th Floor, Room 506. For questions or more information please contact Developmental Therapeutics DevelopmentalTherapeutics@seattlechildrens.org

Islamic apologetics in the International Journal of Cardiology

2010-11-03T21:39:00.000-07:00

from Pharyngula by PZ Myers ...

PZ, a developmental biologist and outspoken atheist comments on an effort to 'discover" science in the Q'ran.

I've run into this particular phenomenon many times: the True Believer in some musty ancient mythology tells me that his superstition is true, because it accurately described some relatively modern discovery in science long before secular scientists worked it out. It's always some appallingly stupid interpretation of a vaguely useless piece of text that wouldn't have made any sense until it was retrofitted to modern science. My particular field of developmental biology has been particularly afflicted with this nonsense, thanks to one man, Dr. Keith L. Moore, of the University of Toronto. He's the author or co-author on several widely used textbooks in anatomy and embryology — and they are good and useful books! — but he's also an idiot. He has published ridiculous claims that the Qur'an contains inexplicably detailed descriptions of the stages of human development, implying some sort of divine source of information.

I've mentioned this before. For instance, the old book claims that at one point the embryo looks like a piece of chewed gum, or mudghah, and Moore announces, "by golly, it does, sorta", throwing away all the knowledge we have about the structure and appearance of the actual embryo, which is not a chewed lump. I've actually seen these kooks show pictures of a piece of gum and an embryo and declare that they are similar. It's insane. It's pareidolia run amuck and swamping out actual scientific information for the sake of propping up useless superstitions.
Here's Moore himself, endorsing the divinity of Allah on the basis of mudghah.

You may not have heard of him before, but I regularly get email from Muslims telling me that as a developmental biologist, I ought to follow Islam because of its insights into embryology, which don't exist. Thanks, Dr Moore, you dumbass.
Well, now the Muslim cranks have another coup, having persuaded some other dumbasses to publish an appallingly bad paper in the International Journal of Cardiology, a credible peer-reviewed journal. Or, at least, formerly credible.
The paper is disgracefully bad. It's basically a compendium of an assortment of references to anatomy and health from the Qur'an, endorsing them as accurate sources of information. For instance, the Qur'an prescribes three techniques for healing, "honey, cupping, and cauterization," and gosh, we now know that "Honey contains the therapeutic contents sugars, vitamins, anti-microbials, among other things"!
Are you impressed yet?

Since this is a cardiology journal, the article also finds it necessary to waste the readers' time with blather about blood and arteries. Here's an example of the Prophet's profound knowledge of the circulatory system.

Another great vessel mentioned in the Qur'an is the Al-Aatín or aorta "We would certainly have seized his right hand and cut off his Al-Watín," [20]. Al-Watín has been translated into different, yet similar words, including "aorta", "life-artery", and simply "artery". This verse is taken to mean that if the Prophet Mohammed was lying about the teachings of God, then God would have grabbed the Prophet Mohammad's arm and cut a vital artery, certainly killing Mohammad. This verse confirms that 1. Blood was indeed viewed as a vehicle for life and 2. The artery directly leading from the heart is vital to survival. By analyzing the different translations and exegesis of Al-Watín, it can be safely assumed that it is the aorta that the author of the Qur'an is referring to in this verse.

Hmmm. So a warlike society that had many soldiers running about chopping into people with swords was aware that cutting major arteries would lead to rapid blood loss and death. I have no idea how they could have figured that out without an omniscient god whispering the explanation into the ears of priests.
The holy book also talks about heart disease, something else a readership of cardiologists would find interesting. Does this sound like well-informed medicine to you?

The Qur'an shares with the Hadeeth a metaphorical description of the heart as a possessor of emotional faculties, thus giving the heart many characteristics that modern science attributes to the brain. As is popularly stated in Islamic culture, every action is dependent upon intentions, and "...what counts is [to God] the intention of your hearts...". These actions, whether "good" or "bad" determine the health of the heart, namely if it is a sound or diseased heart. A diseased heart is one filled with qualities such as doubt, hypocrisy, and ignorance among many others. Possessors of such qualities have a "hardened," diseased heart. Other malaise qualities contributing to a diseased heart includes blasphemy, rejection of truth, deviation, sin, corruption, aggressiveness, negligence, fear, anger, and jealousy, among others.

The authors of the Qur'an and of this paper seem to have confused poetic metaphor with science.
Yeah, the article also repeats Moore's nonsense about embryology. There's much, much more: read the original paper for yourself, or this excellent critique that also points out all the conveniently omitted parts where the Qur'an gets everything completely wrong.
How did this crap manage to get published? Once again, we have a disgraceful failure of peer-review to weed out obvious religious propaganda, allowing an Islamic tract to appear under the guise of a scientific article. Just the fact that the references consist almost entirely of citations to pages of the Qur'an ought to have triggered some concern. I'd like to know what went wrong in the reviewing process that allowed garbage like this to make it onto the pages of the International Journal of Cardiology. Write to the editor and demand an accounting; also make them squirm in embarrassment and appreciate the damage that has been done to their credibility.
And remember: ancient holy books are sources of lies and misinformation, not science.

Breakfast Club, Tue., Nov. 9, 2010: Daniel Kelly

2010-11-02T10:25:00.000-07:00

To view the webcast:
Go to DimDim.com, click on “Join Meeting” and for the room name, type “Vasculata”

DISTINGUISHED LECTURE SERIES

The Center for Cardiovascular Biology Breakfast Club meets on Tuesday mornings under the sponsorship of the Stem Cells and Cardiovascular Repair program project grant and training grants in Cardiovascular Pathology and Cardiology.

Daniel P. Kelly, MD
Scientific Director, Burnham Institute for Medical Research
Orlando, FL

“Transcriptional regulatory circuits controlling mitochondrial function in the developing and diseased heart”

Tuesday, November 9, 2010
9:00 – 10:00 a.m.
UW SLU campus, 815 Mercer Street
Orin Smith Auditorium, Admin Bldg. C

Dr. Daniel Kelly is Professor and Scientific Director of the Sanford-Burnham Medical Research Institute at Lake Nona and Director of the Diabetes and Obesity Research Center. He has made seminal contribution to our understanding of the gene transcriptional regulatory programs controlling myocyte energy metabolism and mitochondrial function. His classic work defines the critical roles of the PPARs, ERRs and PGC- family transcriptional co-activators in regulating cardiac and skeletal muscle metabolism and mitochondrial function in cardiovascular and metabolic diseases.

View:
https://my.dimdim.com/viewRecording/all/vasculata/default/1a44a217-9dc7-4bba-8b2e-211818a8ac88/af9a1aee-7824-497d-8ecb-148f6c6c3685

Download:
https://my.dimdim.com/download/recording/flv/saas/dimdim/all/vasculata/default/1a44a217-9dc7-4bba-8b2e-211818a8ac88/af9a1aee-7824-497d-8ecb-148f6c6c3685

TAPAS: Thursday, Nov. 4, 2010, 2 pm: Suzie Pun

2010-10-28T14:48:00.001-07:00

SLUG presents:
Tapas

Thursday, November 4th, 2010
2:00 p.m.
Brotman Auditorium, 815 Mercer Street

Suzie H. Pun, PhD
Associate Professor, Bioengineering
University of Washington

“Polymers and drug delivery: applications in gene delivery to the brain and small molecule delivery to tumors”

Refreshments served in the lounge outside the auditorium at approximately 1:30pm

For further information on SLUG Tapas Seminars contact
Scott Lundy (slundy@uw.edu)
Jay Gantz (gantz@u.washington.edu)

Postdoctoral Felowship available

2010-10-27T12:57:00.000-07:00

A postdoctoral position is available for those interested in a position working on systems biology of stem cell differentiation.

Interested candidates may send a CV, a cover letter stating research interests and qualifications, and references to Dr. Kai Tan, 2294 CBRB, Department of Internal Medicine, University of Iowa, Iowa City, IA, 52242, or email: kai-tan@uiowa.edu.

(This notice was sent in behalf of Dr. Rong Tian)

Breakfast Club, Tue., Nov. 2, 2010: Brian Hawkins

2010-10-26T11:17:00.000-07:00

To view the webcast:
Go to DimDim.com, click on “Join Meeting” and for the room name, type “Vasculata”

The Center for Cardiovascular Biology Breakfast Club meets on Tuesday mornings under the sponsorship of the Stem Cells and Cardiovascular Repair program project grant and training grants in Cardiovascular Pathology and Cardiology.

Brian J. Hawkins, Ph.D.

Assistant Professor, Anesthesiology and Pain Medicine;
Researcher, Mitochondria and Metabolism Center
University of Washington

“The Contribution of Mitochondrial Reactive Oxygen Species to Cellular Signaling”

Tuesday, November 2, 2010
9:00 – 10:00 a.m.

UW SLU campus, 815 Mercer Street
Orin Smith Auditorium, Admin Bldg. C

To view the webcast, click on: https://my.dimdim.com/viewRecording/all/vasculata/default/340a16a4-3a22-4d04-91ee-18e352283e34/5e843644-a3a5-417d-99e4-5d4ff13d6a49

To download webcast, click on: https://my.dimdim.com/download/recording/flv/saas/dimdim/all/vasculata/default/340a16a4-3a22-4d04-91ee-18e352283e34/5e843644-a3a5-417d-99e4-5d4ff13d6a49

Systems Analysis of Cell Signaling Networks: STRIDE SEMINAR

2010-10-25T13:10:00.000-07:00

The University of Washington's new center for Systems and Translational Research on Infectious Disease, or STRIDE, expects to expand its roster by more than 20 scientists over the next 12 months, as well as grow its proportion of researchers from outside UW.

Doug L Lauffenburger *

Seminar at Orin Smith .. 3PM Tuesday

Systems Analysis of Cell Signaling Networks: Elucidating
Relationships and Logic via Integrated Quantitative Experiment and
Computational Modeling

Stride website: http://www.thestridecenter.com/
http://www.thestridecenter.com/investigators.html

From Lauffenberger's website at MIT: Molecular cell bioengineering is the application of engineering approaches to develop quantitative understanding of cell function in terms of fundamental molecular properties, and to apply this understanding for improved design of molecular- and cell-based technologies. Our research group focuses on elucidating important aspects of receptor-mediated regulation of mammalian blood and tissue cell behavioral functions such as proliferation, adhesion, migration, differentiation, and death. A central paradigm of our work is development and testing of computational models -- based on principles from engineering analysis and synthesis -- for receptor regulation of cell function by exploiting techniques of molecular biology to alter parameters characterizing receptor or ligand properties in well-characterized cell systems. Quantitative experimental assays are used to measure cell functions, receptor/ligand interaction parameters, and signaling network dynamics. Problems are primarily motivated by health care technologies of interest to pharmaceutical and biotechnological companies, and emphasize multi-disciplinary collaborative interactions, including colleagues in both academia and industry.

Breakfast Club, 9am, Tue., Oct. 26, 2010: Wang Wang

2010-10-20T07:59:00.001-07:00

Breakfast Club, 9 am, Tue., October 19, 2010: Steve Schwartz

2010-10-13T12:03:00.000-07:00

To view the webcast:
Go to DimDim.com, click on “Join Meeting” and for the room name, type “breakfastclub” (all lowercase, no space between words).

The Center for Cardiovascular Biology Breakfast Club meets on Tuesday mornings under the sponsorship of the Stem Cells and Cardiovascular Repair program project grant and training grants in Cardiovascular Pathology and Cardiology.

Stephen M. Schwartz, M.D., Ph.D.

Professor, Department of Pathology
University of Washington

“Application of causal analysis to the vessel wall”

Tuesday, October 19, 2010
9:00 – 10:00 a.m.

UW SLU campus, 815 Mercer Street
Orin Smith Auditorium, Admin Bldg. C

Breakfast Club, 9 am, Tue., October 12, 2010: Slava Korshunov

2010-10-05T11:41:00.000-07:00

The Center for Cardiovascular Biology Breakfast Club meets on Tuesday mornings under the sponsorship of the Stem Cells and Cardiovascular Repair program project grant and training grants in Cardiovascular Pathology and Cardiology.

Slava Korshunov, Ph.D.
Assistant Professor of Medicine
Aab Cardiovascular Research Institute
Univ. of Rochester School of Medicine and Dentistry
Rochester, NY

“Mouse genetics is a powerful approach to understand vascular remodeling”

Tuesday, October 12, 2010
9:00 – 10:00 a.m.
UW SLU campus, 815 Mercer Street
Orin Smith Auditorium, Admin Bldg. C

Intersting Postion

2010-09-29T15:39:00.000-07:00

PZ Myers, UMM, Wants to Hire a Tenure Track Biologist! is a biologist and associate professor at the University of Minnesota, Morris.

Aside from his "real work" in embryology, PZ is perhaps the best known biology blogger in the country. His blog is Pharyngula. (http://scienceblogs.com/pharyngula/)

Category: Academics

The UMM biology program is looking to replace a recent retiree, and we need someone who is an excellent teacher, competent to teach cell biology and a basic genetics course, and with some interesting expertise that can be used for upper level electives in your specialty and can provide undergraduate research opportunities. We will need this wonderful person by Fall of 2011, so if you think you fit the bill and want to be involved in an excellent undergraduate teaching program, send an application in soon! The committee here is champing at the bit to find out who our future tenure track colleague will be, so even though it says our screening period is open-ended, we're going to get into action in mid-January and late applications will enter an applicant pool where we're already interviewing people. Don't delay!

Full Time Tenure Track Position in Biology

Required/Preferred Qualifications:
Required: Applicants must hold or expect to receive a Ph.D. in cell biology or a related field by August 15, 2011. Two years experience teaching undergraduate biology is required. (Graduate TA experience is acceptable).

Preferred: Preference will be given to applicants who have an area of expertise relevant to our pre-health professional students and complementary to existing faculty interests. These might include, but are not limited to: immunology, cancer biology, bioinformatics, and cell signaling.

Duties/Responsibilities: Teaching undergraduate biology courses including a sophomore-level cell biology course, an upper-level genetics elective course, an elective in the applicant's area of expertise, and other courses that support the biology program; advising undergraduates; conducting research that could involve undergraduates; and sharing in the governance and advancement of the biology program, the division, and the campus.

Program/Unit Description:
The University of Minnesota, Morris (UMM) is one of the top public liberal arts colleges in the nation. As one of five campuses of the University of Minnesota, UMM has a unique mission and offers the best of both in the world of higher education--a small, close-knit campus complemented by the power of a world-renowned research University system. UMM is located 160 miles WNW of Minneapolis in a small (5000) rural community. Our student body is diverse (19% students of color) and academically well-prepared, with 55% earning an ACT comprehensive score of 25 or higher and over 50% drawn from the top 20% of their high school classes. Our current faculty have received 18 of the University system's highest teaching award and are very active in research and publication. To learn more about the University of Minnesota, Morris visit our website at http://www.morris.umn.edu.

This tenure-track position carries all of the privileges and responsibilities of University of Minnesota faculty appointments. A sound retirement plan, excellent fringe benefits and a collegial atmosphere are among the benefits that accompany the position. Appointment will be at the Assistant Professor level for those having the Ph.D. in hand and at the Instructor level for those whose Ph.D. is pending. The standard teaching load is twenty credit hours per year.

The University of Minnesota is an equal opportunity educator and employer. We are committed to the policy that all persons shall have equal access to its programs, facilities, and employment without regard to race, color, creed, religion, national origin, sex, age, marital status, disability, public assistance status, veteran status, or sexual orientation. To request disability accommodations, please contact Sarah Mattson at 320-589-6021.

Application Instructions:
Applications must include a letter of application, resume, transcripts, a teaching statement (with evidence of teaching effectiveness), a research statement (proposing a research program that is viable at a small liberal arts college and accessible to undergraduates) and three letters of reference. Send applications to:

Biology Search Committee Chair
Division of Science and Mathematics
University of Minnesota, Morris
Morris, MN 56267-2128
Applications will be accepted until the position is filled. Screening begins January 5, 2011. Inquiries can be made to Ann Kolden, Executive Office and Administrative Specialist, at (320) 589-6301 or koldenal@morris.umn.edu.

I know, it says we're small and far away in the hinterland, but don't let that scare you. This really is a great good place to work if teaching is your passion. And if it isn't, we probably don't want you.

Breakfast Club, 9 am, Tuesday,Oct. 5, 2010: Eric Senning

2010-09-29T12:20:00.000-07:00

The Center for Cardiovascular Biology Breakfast Club
Presents:

Eric Senning, PhD
Senior Fellow
Department of Physiology and Biophysics
University of Washington

“Mitochondrial Dynamics as Studied by Fourier Imaging Correlation Spectroscopy”

Tuesday, October 5, 2010
9:00 – 10:00 a.m.
UW SLU campus, 815 Mercer Street
Orin Smith Auditorium, Admin Bldg. C

Breakfast Club, Tue., Sept. 28, 9 am, Edward Cheng

2010-09-22T13:58:00.000-07:00

Edward P. Cheng
Predoctoral Fellow, MD/PhD student
Department of Physiology and Biophysics
University of Washington

“Coupled gating of L-type calcium channels”

Tuesday, September 28, 2010
9:00 – 10:00 a.m.
UW SLU campus, 815 Mercer Street
Orin Smith Auditorium, Admin Bldg. C

Breakfast Club Fall Schedule, Sept. 28-Dec. 7

2010-08-17T13:47:00.000-07:00

The Center for Cardiovascular Biology Breakfast Club announces the
Fall Quarter 2010 Schedule

• September 28 – Edward P. Cheng, Predoctoral Fellow, MD-PhD student, Dept. of Physiology and Biophysics, “Coupled gating of L-type calcium channels”

• October 5 - Eric Senning, PhD, Sr. Fellow, Physiology & Biophysics, “Mitochondrial Dynamics as Studied by Fourier Imaging Correlation Spectroscopy”

• October 12 – Slava Korshunov, PhD, Assistant Professor of Medicine, Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY, “Mouse genetics is a powerful approach to understand vascular remodeling”

• October 19 – Stephen M. Schwartz, MD, PhD, Professor, Pathology, “Application of Causal Analysis to the Vessel Wall”

• October 26 – Wang Wang, MD, PhD, Assistant Professor, Anesthesiology and Pain Medicine, Mitochondria and Metabolism Center, “Mitochondria Production of Reactive Oxygen Species and its Role in Ischemia Reperfusion Injury”

• November 2 – Brian J. Hawkins, PhD, Assistant Professor, Anesthesiology and Pain Medicine; Researcher, Mitochondria and Metabolism Center, “The Contribution of Mitochondrial Reactive Oxygen Species to Cellular Signaling”

• November 9 – Daniel P. Kelly, MD, Scientific Director, Burnham Institute for Medical Research, Orlando, FL, “Transcriptional regulatory circuits controlling mitochondrial function in the developing and diseased heart”

• November 16 – Angie Hertz, Predoctoral Fellow, Pharmacology, “The role of phosphodiesterases in inflammation”

• November 23 – J. Lee Nelson, MD, Member, FHCRC; Professor, Rheumatology, “Microchimerism: for better or for worse?”

• November 30 – Rachel Klevit, D. Phil., Professor, Biochemistry and Biomolecular Structure Center, “Taming the Beast: Structural biology of alphaB-crystallin, a small heat shock protein implicated in cardiomyopathy”

• December 7 – Hannele Ruohola-Baker, Professor, Biochemistry (Title to be announced)

TUESDAYs, 9:00 am (Note new time)
September 28 – December 7, 2010
UW SLU campus, 815 Mercer Street
Orin Smith Auditorium, Admin Bldg. C
(except for Nov. 16 at 8:30 am, Brotman Auditorium)

Vascular Imaging Lab seminar: Yamada, Sept. 7, 2010

2010-08-16T10:00:00.000-07:00

The Vascular Imaging Laboratory
Presents a seminar by:

Kiyofumi Yamada, M.D.
Medical Researcher
Department of Neurosurgery
Gifu University Graduate School of Medicine
Gifu, Japan

“Quantitative tissue characterization of carotid plaques using integrated backscatter ultrasound and its clinical application”

9:00 a.m., Tuesday, September 7, 2010
Brotman Auditorium, 815 Mercer Street

Abstract:

Carotid atherosclerotic disease is a leading cause of stroke. Therapeutic guidelines are based on percentage of stenosis. Recently, however, several studies have shown the critical importance of diagnosing vulnerable plaques, which are associated with a higher risk for stroke, by determining plaque characteristics. Accurate diagnosis of carotid plaque seems to be of paramount clinical importance.
To assess a quantitative tissue characterization of carotid plaques, we have used integrated backscatter ultrasound (IBS). This seminar will discuss the utility, clinical applicability and limitations of IBS for assessing vulnerable plaques.

Parking is available for those with a monthly UW parking permit at the parking lot below the Administration Building; entry is on Republican directly across from Athletic Awards. Have your parking ticket validated at the receptionists’ front desk on the main floor. On-street parking is also available. There is also a shuttle from UWMC to South Lake Union; schedule is at http://www.washington.edu/facilities/transportation/uwshuttles/SouthLakeUnionShuttle/schedule-hsb.

2010-07-07T17:35:00.000-07:00

Survival Skills for the Research Years
An Annual University of Washington
Department of Medicine Workshop
Everything fellows and new faculty
need to know to thrive in academics

When: July 15‐16, 2010
8:30am‐4:00pm

Where: South Lake Union
Conference 815

To register, please visit:
https://depts.washington.edu/flworien/

Contact
206.543.7318
gfranco@uw.edu